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:: Volume 11, Issue 11 (January 2018) ::
Qom Univ Med Sci J 2018, 11(11): 22-32 Back to browse issues page
The Effect of Hydroalcoholic Extract of Salvia leriifolia Root and Fluvoxamine on the Spatial Memory in Male Rats under Immobilization Stress
Soudeh Erish 1, Mehdi Mohammadzadeh 2, Minoo Ilkhanipour 2, Farrin Babaei 2
1- 1Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran. , soarish1366@gmail.com
2- assistant professor 1Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran.
Abstract:   (567 Views)
Background and Objectives: Oxidative stress causes damage in processes, such as learning and memory through affecting the nervous system. Also, using chemical drugs for treatment of stress-induced depression is often associated with attenuation of memory. In the present study, the effect of hydroalcoholic extract of Noroozak (Salvia leriifolia) root as an antioxidant along with antidepressant drug, fluvoxamine, were investigated on the spatial memory of male rats under immobilization stress.  
 
Methods: In this experimental study, 25 adult male rats (mean weight, 170g), were randomly divided into five groups of 5 each. The animals were orally treated with different doses of drug and extract for 21 days. At the end of the treatment period, a radial 8-arm maze was used to investigate the behavioral indices. Also, malondialdehyde and catalase levels in the brain tissue homogenate and glucose and cortisol levels in blood, were measured. Data analysis was carried out using one-way analysis of variance and post-hoc Tukey’s test.
 
Results: Spatial memory in the rats under immobilization stress (sham group) showed a significant decrease as compared to the control group. Administration of extract of Noroozak root improved the spatial memory in the groups receiving extract and extract-drug compared to sham and fluvoxamine groups. Also, the extract of Noroozak root improved the flovoxamine-induced attenuation of memory, increased catalase, and decreased malondialdehyde, glucose, and cortisol in the groups under treatment with extract and extract-drug compared to sham group.
 
Conclusion: The findings showed that immobilization stress and fluvoxamine administration for the treatment of stress-induced depression resulted in attenuation of spatial memory; while, the extract of Noroozak root improved memory in all groups due to powerful antioxidant property.
 
 
Keywords: Restraint, Physical, Spatial memory, Salvia leriifolia, Fluvoxamine, Radial maze.
Full-Text [PDF 610 kb]   (122 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2016/07/25 | Accepted: 2016/09/13 | Published: 2018/01/15
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Erish S, Mohammadzadeh M, Ilkhanipour M, Babaei F. The Effect of Hydroalcoholic Extract of Salvia leriifolia Root and Fluvoxamine on the Spatial Memory in Male Rats under Immobilization Stress. Qom Univ Med Sci J . 2018; 11 (11) :22-32
URL: http://journal.muq.ac.ir/article-1-1041-en.html
Volume 11, Issue 11 (January 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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