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:: Volume 10, Issue 6 (August 2016) ::
Qom Univ Med Sci J 2016, 10(6): 68-74 Back to browse issues page
An Investigation of Antibiotic Resistance Pattern in the Strains of Methicillin-resistant Staphylococcus epidermidis Isolated From Clinical Samples in Isfahan Province, Iran
Fahimeh Nourbakhsh *1, Hassan Momtaz 2
1- 1Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , fahimeh_nourbakhsh@yahoo.com
2- 1Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Abstract:   (898 Views)

Background and Objectives: Staphylococcus epidermidis is one of the effective factors causing nosocomial infections. This study was performed to investigate the antibiotic resistance pattern in the methicillin-resistant S. epidermidis strains isolated from clinical samples in Isfahan Province.

Methods: In this descriptive cross-sectional study, 150 isolates of S. epidermidis were isolated from detected from the patients hospitalized in hospitals and treatment centers of Isfahan City. The antibiotic resistance pattern was evaluated by disk diffusion method. The presence of the gene encoding antibiotic resistance to methicillin (mec A) in the isolates were investigated using PCR method. Data were analyzed with Chi-square and Fisher's exact statistical tests.

Results: In this study, most isolates were related to urinary tract infections. The highest resistance was reported to penicillin (98.9%), erythromycin (89.4%), ciprofloxacin (77.7%), clindamycin (65.9%), tetracycline (63.2%), and meticillin (54%). None of the strains showed resistance to vancomycin and linezolid. Molecular studies indicated the presence of mecA gene in 76% of the studied isolates.

Conclusion: According to the results of this study, vancomycin and linezolid antibiotics can be the best choice of treatment for infections caused by S. epidermidis. Also, high resistance of S. epidermidis can be a serious warning for increased multiple antibiotic resistance. Molecular studies are indicative of high sensitivity of molecular methods in the investigation of methicillin-resistant isolates.

Keywords: Staphylococcus epidermidis, Drug resistance, Microbial, Isfahan, Iran.
Full-Text [PDF 140 kb]   (460 Downloads)    
Type of Study: Original Article |
Received: 2016/08/15 | Accepted: 2016/08/15 | Published: 2016/08/15
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Nourbakhsh F, Momtaz H. An Investigation of Antibiotic Resistance Pattern in the Strains of Methicillin-resistant Staphylococcus epidermidis Isolated From Clinical Samples in Isfahan Province, Iran. Qom Univ Med Sci J . 2016; 10 (6) :68-74
URL: http://journal.muq.ac.ir/article-1-1099-en.html
Volume 10, Issue 6 (August 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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