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Qom Univ Med Sci J 2012, 6(2): 37-44 Back to browse issues page
Evaluating Antimutagenic Activity of Probiotic Bacteria Isolated from Probiotic Products
R Kazemi Darsanki *1, N Ghaemi2, MS Mirpour3, F Mirdavoudi3
1- Islamic Azad University, Lahijan Branch , reza_kazemi_d@yahoo.com
2- Tehran University
3- Islamic Azad University, Lahijan Branch
Abstract:   (2401 Views)

Background and Objectives: Probiotic bacteria are microbial nutrition supplements which have useful effects on human health by maintaining of bowel microbial balance. There are many studies that have been suggested the use of probiotic products as cancer risk reducer. The aim of this study, is isolation and detection of probiotic agents from yoghurt and probiotical tablet and evaluation of their abilities to decrease some effects of mutagenic and carcinogenic agents.   Methods: In this study, probiotic bacteria were isolated from yogurt and probiotic tablet by using MRS in anaerobic condition (5% Co 2 and gas peck) and temperature of 37°c. Then, they were detected by using biochemical tests. Their anti mutagenic effects of supernatant culture were evaluated against mutagenic agents of azid Sodium and Potassium Permanganate by ames test ( Salmonella typhimurium TA100 ) in presence and absence of S 9 .   Results: Six probiotic bacteria were isolated from yogurt and probiotic tablet. Their anti mutagenic activity results based on ames test showed they can inhibit mutagenic agents more than 40% in some species, which is considered as a good result. Conclusion: The results of this study show that the use of probiotic bacteria found in different products such as yogurt and probiotic tablets, have proper anti mutagenic and anti carcinogenic effects. They change the micro flora of bowel and, as a result, reduce absorption of mutagenic and carcinogenic agents and help to maintain human health.  

Keywords: Probiotics, Antimutagenic Agent, Ames Test, Anti Mutagenicity
Full-Text [PDF 174 kb]   (1230 Downloads)    
Type of Study: Original Article |
Received: 2016/02/13 | Accepted: 2016/02/22 | Published: 2016/02/22
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Kazemi Darsanki R, Ghaemi N, Mirpour M, Mirdavoudi F. Evaluating Antimutagenic Activity of Probiotic Bacteria Isolated from Probiotic Products. Qom Univ Med Sci J. 2012; 6 (2) :37-44
URL: http://journal.muq.ac.ir/article-1-111-en.html


Volume 6, Issue 2 (6-2012) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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