[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Issue 3 (May 2017) ::
Qom Univ Med Sci J 2017, 11(3): 1-10 Back to browse issues page
The Effect of Hydroxylated Fullerene Nanoparticles on Antioxidant Defense System in Brain Ischemia Rat
Mohammad Taghi Mohammadi 1
1- Baqiyatallah University of Medical Sciences
Abstract:   (359 Views)

Background and Objectives: According to the previous findings, brain ischemia attenuates the brain antioxidant defense system. This study aimed to investigate the effect of hydroxylated fullerene nanoparticle on antioxidant defense system in ischemic brain rat.

Methods: In this Experimental study, rats were divided into three groups (n=6 in each group): sham, ischemic control, and ischemic treatment group. Brain ischemia was induced by middle cerebral artery (MCA) occlusion for 90 minutes followed by a 24-hour reperfusion. Ischemic treatment animals received fullerene nanoparticles intraperitoneally at a dose of 10mg/kg immediately after the end of MCA occlusion. After 24-h reperfusion period, brain catalase and superoxide dismutase (SOD), and glutathione activities were assessed by biochemical methods. The data were analyzed using one-way ANOVA and Tukey post-hoc test.

Results: The mean glutathione level and catalase and SOD activities in sham animals were 1±0.18%, 1±0.20%, and 1±0.04%, respectively. Induction of brain ischemia decreased the value of glutathione level and catalase and SOD activities in control ischemic rats and their values were obtained to be 0.55±0.09%, 0.44±0.05%, and 0.86±0.02%, respectively. Fullerene significantly increased the activities of catalase (0.93±0.29%) and SOD (1.33±0.22%) in ischemic treatment group compared to ischemic control rats, but did not change the glutathione level (0.52±0.25%).

Conclusion: The results of this study showed that treatment with fullerene nanoparticles improves the brain antioxidant defense system, which is weakened during brain ischemia, through increasing catalase and SOD activities.

Keywords: Brain ischemia, Hydroxylated fullerene, Antioxidants, Immune system
Full-Text [PDF 643 kb]   (224 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2016/09/17 | Accepted: 2016/09/26 | Published: 2017/05/18
Add your comments about this article
Your username or Email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mohammadi M T. The Effect of Hydroxylated Fullerene Nanoparticles on Antioxidant Defense System in Brain Ischemia Rat. Qom Univ Med Sci J . 2017; 11 (3) :1-10
URL: http://journal.muq.ac.ir/article-1-1169-en.html
Volume 11, Issue 3 (May 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.127 seconds with 800 queries by yektaweb 3510