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:: Volume 10, Number 7 (September 2016) ::
Qom Univ Med Sci J 2016, 10(7): 20-28 Back to browse issues page
Comparison of the Effects of Aqueous Aloe vera Extract and Theophylline on the Histological Changes of Kidney and Renal Factors in Female Rats with Asthma
Nahid Gholizade *1, Farah Farokhi2
1- University of Nazloo , rooz.gholizadeh@yahoo.com
2- University of Nazloo
Abstract:   (740 Views)

Background and Objectives: Asthma is a kind of respiratory disease for which different chemical and herbal drugs are used. This study investigated the side effects of theophylline (TEO) and Aloe vera extract (AVE) on kidney tissue in rats with asthma.

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Methods: Thirty six female rats were divided into six groups of six each. Asthma was induced in the rats using acetic acid spray for 12 weeks. At completion of this period, heart blood samples were collected to conduct biochemical tests. Kidney tissue was fixed in formalin 10% and stained with hematoxylin and eosin for microscopic examinations. The data were analyzed by variance and Tukey's test.

Results: Inflammatory cells were seen in connective tissue and around renal tubules. In TEO-treated group, mild change in  density of mesenchymal stem cells, atrohpy of glumeral capillaries, and increase in Bowman space were seen, but in AVE (100mg/kg)-treated group, kidney improved. The mean creatinine and urea concentrations increased in rats with asthma and TEO and AVE (200mg/kg)-treated rats compared to the controls (p<0.05) but significantly decreased in AVE (100mg/kg)-treated rats (p<0.05).

Conclusion: AVE (100mg/kg) is effective in reducing inflammation of the kidney and concentrations of urea and creatinine.

Keywords: Asthma, Aloe Vera, Theophylline, Kidney, Rats
Full-Text [PDF 549 kb]   (375 Downloads)    
Type of Study: Original Article | Subject: علوم پایه
Received: 2016/09/18 | Accepted: 2016/09/18 | Published: 2016/09/18
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Gholizade N, Farokhi F. Comparison of the Effects of Aqueous Aloe vera Extract and Theophylline on the Histological Changes of Kidney and Renal Factors in Female Rats with Asthma. Qom Univ Med Sci J . 2016; 10 (7) :20-28
URL: http://journal.muq.ac.ir/article-1-1171-en.html
Volume 10, Number 7 (September 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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