[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 10, Issue 7 (September 2016) ::
Qom Univ Med Sci J 2016, 10(7): 89-99 Back to browse issues page
Immune Responses Involved in Mycobacterium Tuberculosis Infection
Roghayeh Teimourpour 1, Ehsan Aryan 2, Zahra Meshkat *3
1- Ardabil University of Medical Sciences
2- Mashhad University of Medical Sciences
3- Mashhad University of Medical Sciences , meshkatz@mums.ac.ir
Abstract:   (1595 Views)

Background and Objectives: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Approximately one-third of the world's population is infected with M. tuberculosis. Despite the availability of drug and vaccine, it remains one of the leading causes of death in humans especially in developing countries. Epidemiological studies have indicated that only 10-30% of people exposed to tubercle bacillus are infected with M. tuberculosis, and at least 90% of the infected people finally do not acquire TB. The studies have indicated that the host efficient immune system has essential roles in the control of TB infection such that the highest rate of mortality and morbidity is seen in immunocompromised patients such as people infected with HIV.

M. tuberculosis is an obligatory intracellular bacterium. It enters the body mainly through the respiratory tract and alveolar macrophages combat this pathogen most commonly. In addition to alveolar macrophages, various T-cell subpopulations need to be activated to overcome this bacterium's resistance to the host defense systems. CD4+ T cells, through production of several cytokines such as IFN-γ and TNF-α, and CD8+ T cells, through cytotoxic activities and induction of apoptosis in infected cells, play critical roles in inducing appropriate immune responses against M. tuberculosis.

Although cell-mediated immunity is the cornerstone of host responses against TB and the recent studies have provided evidence for the importance of humoral and innate immune system in the control of TB, a profound understanding of the immune responses would provide a basis for development of new generations of vaccines and drugs. The present study addresses immune responses involved in M. tuberculosis infection.

Keywords: Mycobacterium tuberculosis, CD8+ T cells, Immunity, innate, CD4+ T cell, humoral
Full-Text [PDF 931 kb]   (1196 Downloads)    
Type of Study: Original Article | Subject: علوم آزمایشگاهی
Received: 2016/09/19 | Accepted: 2016/09/19 | Published: 2016/09/19
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Teimourpour R, Aryan E, Meshkat Z. Immune Responses Involved in Mycobacterium Tuberculosis Infection. Qom Univ Med Sci J . 2016; 10 (7) :89-99
URL: http://journal.muq.ac.ir/article-1-1177-en.html
Volume 10, Issue 7 (September 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.127 seconds with 803 queries by yektaweb 3510