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:: Volume 10, Issue 8 (October 2016) ::
Qom Univ Med Sci J 2016, 10(8): 27-35 Back to browse issues page
The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats
Mousa Khalafi *1, Shabkhiz Fatemeh Shabkhiz 2, Mohammadreza Zolfaghari 3, Yashar Zarei 2
1- University of Guilan , mousa.khalafi@yahoo.com
2- University of Tehran
3- University of Urmia
Abstract:   (1035 Views)

Abstract

Background and Objectives: Chemerin is a novel adipokine, which plays a key role in the pathological process of insulin resistance and inflammation; clinical studies have shown that chemerin levels increase in diabetic patients. However, the acute effect of exercise on chemerin is not known. In this research, serum changes of chemerin in diabetic male rats were investigated in response to two types of exercise.

Methods: In this experimental study, 29 diabetic male rats (age, 12 weeks; weight, 220-240g) were assigned to 5 groups, including immediately and 2 hours after high-intensity interval exercise (HIIE0, HIIE2), immediately and 2 hours after moderate-intensity continuous exercise (MICE0, MICE2), and control (C). Both MICE groups exercise on treadmill (intensity, 60-65% vo2max) for 40 min,  and both HIIE groups (with intensity of 90-95% vo2max) in 12 one-minute intervals with one-minute rest intervals. ELISA technique was used to measure serum chemerin. Data were analyzed using one-way ANOVA and post-hoc Tukey's test. The level of significance was considered at 0.05.

Results: Serum chemerin levels in MICE0, MICE2 groups and HIIE2 groups, significantly increased compared to the control group (p˂0.05). However, there was no significant difference between HIIE0 group and control group (p>0.05). There was significant difference between MICE0 and HIIE2 groups with HIIE0 group (p˂0.05).

Conclusion: The results of the present research showed that acute exercise leads to increase in serum chemerin in diabetic male rats.

Keywords: Chemerin protein, rat; Exercise; Diabetes mellitus.

Keywords: Chemerin protein, rat, Exercise, Diabetes mellitus
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Type of Study: Original Article | Subject: فیزیولوژی ورزشی
Received: 2016/10/27 | Accepted: 2016/10/27 | Published: 2016/10/27
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Khalafi M, Fatemeh Shabkhiz S, Zolfaghari M, Zarei Y. The Effect of Two Types of Exercise on Serum Chemerin in Diabetic Male Rats. Qom Univ Med Sci J . 2016; 10 (8) :27-35
URL: http://journal.muq.ac.ir/article-1-1252-en.html
Volume 10, Issue 8 (October 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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