[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Issue 12 (February 2018) ::
Qom Univ Med Sci J 2018, 11(12): 25-34 Back to browse issues page
The Effect of 12 Weeks of Submaximal Swimming Exercise on Resting Levels of VEGF in Rats Exposed to Nicotine-Derived Nitrosamine Ketone
Ali Barzegari 1, Shadmehr Mirdar 2
1- 1Department of Physical Education & Sport Sciences, Payame Noor University, Tehran, Iran.
2- 2Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Mazandaran, Babolsar, Iran. , shadmehr.mirdar@gmail.com
Abstract:   (400 Views)
Background and Objectives: Tobacco contains carcinogens, such as nitrosamine ketone (NNK), which play a role in induction of lung cancer through stimulation of vascular endothelial growth factor (VEGF) expression. The aim of this study was to investigate changes in resting levels of VEGF in lung tissues of rats exposed to nicotine-derived NNK following 12 weeks of aerobic submaximal swimming exercise.
 
Methods: In this experimental study, 46 mature Wistar rats, were randomly divided into five groups, including: exercise, exercise + NNK, NNK, solvent, and control. The groups induced by NNK, received NNK subcutaneously once per week at a rate of 12.5mg/kg body weight for 12 weeks. The training groups performed submaximal swimming exercise for 12 weeks. The levels of VEGF in homogenized lung tissue were measured by ELISA. Data analysis was performed using one-way ANOVA and Tukey's tests at a significance level of p≤0.05.
 
Results: In this study, a period of swimming training program significantly decreased the levels of VEGF in lung tissue compared to control (p=0.039) and NNK (p≤0.001) groups. A significant reduction was also observed in the VEGF level in exercise + NNK group compared to NNK group (p≤0.001). Furthermore, VEGF levels significantly increased in NNK group compared to exercise (p≤0.001), exercise+NNK (p≤0.001), and solvents (p≤0.001) groups.
 
Conclusion: Overall, it can be concluded that regular submaximal aerobic exercise plays an effective role in the inhibition of NNK-induced lung
 
Keywords: Swimming, Vascular endothelial growth factor A, Nitrosamine, Ketones, Nicotine.
Full-Text [PDF 709 kb]   (122 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی ورزشی
Received: 2016/11/14 | Accepted: 2016/12/19 | Published: 2018/02/19
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

barzegari A, mirdar S. The Effect of 12 Weeks of Submaximal Swimming Exercise on Resting Levels of VEGF in Rats Exposed to Nicotine-Derived Nitrosamine Ketone. Qom Univ Med Sci J . 2018; 11 (12) :25-34
URL: http://journal.muq.ac.ir/article-1-1294-en.html
Volume 11, Issue 12 (February 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.2 seconds with 31 queries by YEKTAWEB 3705