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:: Volume 12, Issue 3 (May 2018) ::
Qom Univ Med Sci J 2018, 12(3): 19-27 Back to browse issues page
Evaluation of effect the cyclic lipopeptides from Bacillus atrophaeus HNSQJYH170 on Candida species
Solmaz Moghtadi pisheh 1 , Mahboobeh Madani 2
1- The Effect of Cyclic Lipopeptides of Bacillus atrophaeus (HNSQJYH170) on Candida Species
2- The Effect of Cyclic Lipopeptides of Bacillus atrophaeus (HNSQJYH170) on Candida Species , mmadani66@gmail.com
Abstract:   (87 Views)

Background and Objectives: In humans, during the recent years, several factors have increased the risk of fungal infections, like broad spectrum antibiotics, immune compromised patients, cytotoxic chemotherapy and transplantations. Among all fungal pathogens Candida species remain the most common cause of invasive fungal infections. The aim of the current study is extraction of lipopeptides from Bacillus atrophaeus HNSQJYH170 isolated from Isfahan, and the study of its antifungal effects against Candida species.

Methods: After 72 h of incubation, a cell-free supernatant of Bacillus atrophaeus was collected by centrifugation and acidified by adding HCl. The precipitate obtained was collected by centrifugation and dissolved in the methanol solution (50 ). Then antifungal activity of lipopeptides was evaluated by well diffusion method against Candida species. Also inhibition effect of lipopeptide on germ tube production for Candida albicans was studied.

Results: There was no Inhibition zone for Candida species by cyclic lipopeptides. Inhibition of germtube production in %95 of C.albicans cells was showed by Bacillus atrophaeus lipopeptides.

Conclusion: The results of this study showed that, although lipopeptides extracted from Bacillus atrophaeus were not able to inhibit Candida spp but inhibition of germtube production in %95 of C.albicans cells was showed. The ability of lipopeptides in inhibition of germtube production in C.albicans was showed, that these compounds can prevent biofilm formation on catheters and other substrate. Therefore, these compounds are important in preventing the invasion C.albicans of mucosal.

Keywords: Bacillus atrophaeus, cyclic lipopeptides, Candida

Keywords: Keywords: Bacillus atrophaeus, cyclic lipopeptides, Candida
Full-Text [PDF 460 kb]   (21 Downloads)    
Type of Study: Original Article | Subject: قارچ شناسی
Received: 2017/02/6 | Accepted: 2017/05/13 | Published: 2018/05/17
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Moghtadi pisheh S, madani M. Evaluation of effect the cyclic lipopeptides from Bacillus atrophaeus HNSQJYH170 on Candida species. Qom Univ Med Sci J . 2018; 12 (3) :19-27
URL: http://journal.muq.ac.ir/article-1-1471-en.html
Volume 12, Issue 3 (May 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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