[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 5 (July 2018) ::
Qom Univ Med Sci J 2018, 12(5): 6-15 Back to browse issues page
The Role of 5HT3 Receptor Antagonist of the Lateral Hippocampus on Amnesia Induce by Morphine in Mice
Hanieh Alsadat Lavasani 1, Bahareh Pakpour * 2, Majid Navaian 3
1- Azad University, Central Tehran branch
2- Azad University, Central Tehran branch , b_pakpour@yahoo.com
3- Azad University, Shahr-e-reybranch
Abstract:   (1083 Views)
Background and Objectives: Learning and memory processes occur as a result of interaction of neurotransmitter systems in various brain regions, such as hippocampus. The evidences indicated that serotonergic and opioidergic systems involve in behavioral, learning, and memory results. In the present study, we investigated the effect of the serotonergic system (5-HT) of the lateral hippocampus (CA1) on morphine-induced amnesia.
Methods: In this experimental study, the animals were bilaterally implanted with cannulas in the CA1 region of the lateral hippocampus. Morphine was injected intraperitoneally and 5-HT3 receptor antagonist (Y-25130) was injected into the CA1 region. The memory was assessed by a single-trial step-down passive avoidance task and tested after training. The step-down latency was used for the assessment of memory retention in adult male NMRI mice. One-way analysis of variance, followed by Tukey test, were used for the analysis of data.
Results: In this study, pre-test injection of morphine (dose, 5mg/kg) and Y-25130 (dose, 1ng/mouse) decreased memory acquisition process in the adult mice. In addition, ineffective dose of Y-25130 (0.01ng/mouse) along with ineffective dose of morphine (5mg/kg) induced amnesia in mice.
Conclusion: The results of this study showed that there is a synergistic effect between 5-HT3 receptor antagonists of hippocampal CA1 region and morphine.
Keywords: Memory, Serotonin, Morphine, Mice, Passive avoidance.
Full-Text [PDF 539 kb]   (214 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2017/05/27 | Accepted: 2017/08/1
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Lavasani H A, Pakpour B, Navaian M. The Role of 5HT3 Receptor Antagonist of the Lateral Hippocampus on Amnesia Induce by Morphine in Mice. Qom Univ Med Sci J. 2018; 12 (5) :6-15
URL: http://journal.muq.ac.ir/article-1-1657-en.html

Volume 12, Issue 5 (July 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.2 seconds with 32 queries by YEKTAWEB 3855