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:: Volume 11, Number 5 (July 2017) ::
Qom Univ Med Sci J 2017, 11(5): 53-62 Back to browse issues page
The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
Rahemeh Jahangiri Jahangiri1, Parvin Farzanegi *1, Masoumeh Habibian Habibian2
1- Department of Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari, Iran.
2- 2Department of Physical Education, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran.
Abstract:   (237 Views)

Background and Objectives: Diabetes is one of the most important metabolic diseases, which its incidence rate has increased in recent years. In this disease, the insulin function is impaired, leading to several complications. Physical exercise and medicinal plants are considered as a way to control diabetes along with nutrition and medicine. The present study was conducted with the purpose of determining the effect of aerobic training and use of arbutin on cardiac nitric oxide, tumor necrosis factor-α and vessel endothelial growth factor in male diabetic rats.

Methods: In this experimental study, 42 male adult Wistar rats (age, 8 weeks; weight, 190-220g), were randomly divided into 6 groups of 7 each (control, arbutin, diabetic, diabetic+training, diabetic+arbutin, and diabetic+training+arbutin). Training programs included 5 days of swimming per week for 6 weeks. Sampling from the heart was performed 72 hours after the last training session and arbutin consumption to analyze NO, TNF-α and VEGF. Data were analyzed using one-way ANOVA at the significance level p≤0.05.

Results: Aerobic training along with use of arbutin led to increased levels of NO and VEGF and decreased level of TNF-α in cardiac tissue of diabetic rats (p<0.001).

Conclusion: The results indicated that a period of regular aerobic training and use of arbutin can be considered as an appropriate non-medicinal method to control diabetes mellitus type 2 through decrease in inflammatory factors.

Keywords: Exercise, Arbotin, Nitric oxide, Tumor necrosis Factor-alpha, Vascular Endothelial growth factor A, Diabetes mellitus
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Type of Study: Original Article | Subject: علوم پایه
Received: 2017/07/19 | Accepted: 2017/07/19 | Published: 2017/07/19
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Jahangiri R J, Farzanegi P, Habibian M H. The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats. Qom Univ Med Sci J . 2017; 11 (5) :53-62
URL: http://journal.muq.ac.ir/article-1-1748-en.html
Volume 11, Number 5 (July 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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