[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 10 (December 2018) ::
Qom Univ Med Sci J 2018, 12(10): 36-45 Back to browse issues page
Evaluation of Antimicrobial and Anti-Quorum Sensing Activity of Mazouj and Ghalghaf Galls Extracts of Oak against Pseudomonas aeruginosa
Shideh Fatehi1 , Maryam Mohammadi-Sichani 2, Majid Tavakoli3
1- Department of Microbiology, Falavarjan Branch, Islamic Azad University
2- Department of Microbiology, Falavarjan Branch, Islamic Azad University , mohamadi_m@iaufala.ac.ir
3- Agricultural & Natural Resources Research Center of Lorestan
Abstract:   (1145 Views)
Background and Objectives: Infections caused by resistant Pseudomonas aeruginosa strains mostly originate from hospitals, and its prevalence is increasing in many countries of the world. Therefore, many efforts have been made to find new active plant compounds as an appropriate substitute for antibiotics. The purpose of this study was to evaluate the active compounds, antibacterial and antibiofilm activity of aqueous and methanol extracts of Mazuj and Ghalghaf galls against Pseudomonas aeruginosa.
Methods: This study was performed on standard strain of Pseudomonas aeruginosa and a number of clinical strains. The methanol and aqueous extract of Mazuj and Ghalghaf galls, were prepared by Soxhlet method. Antibacterial activity of the extracts was assessed by well diffusion method, minimum inhibitory concentration (MIC) by microdilution method. The anti-quorum sensing activity of methanol and aqueous extracts of Mazuj and Ghalghaf galls was investigated on anti-biofilm activity of Pseudomonas aeruginosa.
Results: The methanol and aqueous extracts of Mazuj and Ghalghaf galls showed antibacterial activity against Pseudomonas aeruginosa. The MIC values of the extracts were obtained to be 6.25 - 25 mg/ml. The extracts of Mazuj and Ghalghaf galls inhibited the formation of Pseudomonas aeruginosa biofilms in concentrations higher than 6.25.
Conclusion: According to the results of this study, the extracts of Mazuj gall have appropriate antibacterial activity against the studied bacteria. Also, the methanol extract had higher antibacterial activity than the aqueous extract. Therefore, it is suggested that more extensive research be conducted on the identification of its antimicrobial compounds as a suitable alternative to antibiotics for the treatment of diseases.
Keywords: Plant extract, Anti-infective agents, Pseudomonas aeruginosa, Mazuj gall, Ghalghaf gall, Active constituents, Antibacterial activity.
Full-Text [PDF 1125 kb]   (197 Downloads)    
Type of Study: Original Article | Subject: میکروب شناسی
Received: 2018/01/16 | Accepted: 2018/08/18
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fatehi S, Mohammadi-Sichani M, Tavakoli M. Evaluation of Antimicrobial and Anti-Quorum Sensing Activity of Mazouj and Ghalghaf Galls Extracts of Oak against Pseudomonas aeruginosa. Qom Univ Med Sci J. 2018; 12 (10) :36-45
URL: http://journal.muq.ac.ir/article-1-1997-en.html


Volume 12, Issue 10 (December 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.22 seconds with 32 queries by YEKTAWEB 3921