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:: Volume 12, Issue 10 (December 2018) ::
Qom Univ Med Sci J 2018, 12(10): 9-15 Back to browse issues page
The Cytotoxic Effect of Metformin on Cervical Cancer (Hela) Cells in Comparison with Non-Cancerous Kidney Cells
Zahra Gholamhoseyni 1 , Rahim Ahmadi * 2, Yeganeh Hamidi 3
1- Department of Physiology, Faculty of Basic Sciences, Hamadan Branch, Islamic Azad University
2- Department of Biology, Faculty of Basic Sciences, East Tehran Branch, Islamic Azad University , rahahmadi2001@yahoo.com
3- Department of Biology, Faculty of Basic Sciences, East Tehran Branch, Islamic Azad University
Abstract:   (525 Views)
Background and Objectives: Studies have shown that antidiabetic drugs can inhibit cancer cells proliferation. The aim of this study was to investigate the cytotoxic effects of metformin on cervical cancer (Hela) cells in comparison with non-cancerous kidney cells (Hek293).
Methods: In this laboratory experimental study, Hela and Hek293 cells were purchased from Pasteur Institute Cell Bank and divided into group receiving metformin (at doses of 0.001, 0.01, 0.1, 1, and 10 mg/ml) and control group. Cytotoxic effect of metformin on cell line, was measured using MTT assay method. Data were analyzed using one-way ANOVA.
Results: Exposure of Hela cells to 0.01, 0.1, 1, and 10 mg/ml of metformin resulted in significant decrease in cell viability compared to the control group, however, exposure of Hek293 cells to metformin concentrations did not significantly change cell viability.
Conclusion: The results of this study indicated that exposure to metformin can reduce viability of cervical cancer cells but had no significant cytotoxic effects on non-cancerous cells. Accordingly, use of metformin should be considered for treatment and prevention of cervical cancer.
Keywords: Metformin, Cell survival, Hela cells, Hek293 cells
Full-Text [PDF 689 kb]   (146 Downloads)    
Type of Study: Original Article | Subject: pharmacology
Received: 2018/07/28 | Accepted: 2018/08/28
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Gholamhoseyni Z, Ahmadi R, Hamidi Y. The Cytotoxic Effect of Metformin on Cervical Cancer (Hela) Cells in Comparison with Non-Cancerous Kidney Cells. Qom Univ Med Sci J. 2018; 12 (10) :9-15
URL: http://journal.muq.ac.ir/article-1-2186-en.html


Volume 12, Issue 10 (December 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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