[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 3 (May 2019) ::
Qom Univ Med Sci J 2019, 13(3): 32-39 Back to browse issues page
The Effect of Simultaneous Oral Consumption of Camel Milk and Urine on Cirrhosis Liver Model Induced by Carbon Tetrachloride in Male Rats
Shima Ababzadeh 1 , Soroush Sharifimoghadam 2 , Shahin Eftekhari Seyyed2 , Mohsen Eslami Farsani 3 , Navid Hasanzadeh 4 , Azam Moslehi * 5
1- Department of Physiology, Cellular & Molecular Research Center, Qom University of Medical Sciences
2- Student Research Committee, School of Medicine, Qom University of Medical Sciences
3- Department of Anatomy, School of Medicine, Qom University of Medical Sciences
4- Qom University of Medical Sciences
5- Qom University of Medical Sciences , molehi2000@gmail.com
Abstract:   (219 Views)
Background and Objectives: Special features of camel urine and milk have caused their wide consumption in Islamic and traditional medicine as an anti-microbial, antioxidant, and liver protective substance. The present study was conducted to evaluate the effect of camel urine and milk in carbon tetrachloride (CCL4) induced cirrhosis.
 
Methods: Twenty-four male rats were randomly divided into 6 groups (control, received olive oil, CCL4, camel milk treated, camel urine treated, and camel urine-milk treated). The CCL4-induced cirrhosis model in groups 3 to 6, was intraperitoneal injection of CCL4. Rats in control, olive oil, and CCL4 groups, intraperitoneally received CCL4 to induce cirrhosis. In the treatment groups, camel milk, urine, and their combination were gavaged respectively. Initial and final body weight as well as serum levels of AST, ALT, ALP, albumin and triglyceride and total cholesterol, were measured in all groups. Liver morphology was assessed using Hematoxellin-Eosin (H&E) staining. Data statistical analysis was carried out using one way ANOVA and Tukey post-hoc (in case of significance) tests.
 
Results: In this study, Serum level of AST, ALT and ALP significantly increased in the CCL4 group compared to the control group, there was no significant difference in the body weight among most groups; but only the simultaneous consumption of camel’s milk and urine in cirrhotic rats decreased the serum levels of ALT, ALP, and triglyceride compared to the CCL4 group.
 
Conclusion: the findings of the present study indicated that simultaneous consumption of camel urine and milk improve cell damage induced by CCL4.
 
Keywords: Came, l milk, urine, Carbon Tetrachloride, Liver cirrhosis, Rat
Full-Text [PDF 488 kb]   (41 Downloads)    
Type of Study: Original Article | Subject: آناتومی
Received: 2018/08/25 | Accepted: 2019/02/24
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ababzadeh S, Sharifimoghadam S, Eftekhari S, Eslami Farsani M, Hasanzadeh N, Moslehi A. The Effect of Simultaneous Oral Consumption of Camel Milk and Urine on Cirrhosis Liver Model Induced by Carbon Tetrachloride in Male Rats. Qom Univ Med Sci J. 2019; 13 (3) :32-39
URL: http://journal.muq.ac.ir/article-1-2219-en.html


Volume 13, Issue 3 (May 2019) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.2 seconds with 32 queries by YEKTAWEB 3862