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:: Volume 13, Issue 3 (May 2019) ::
Qom Univ Med Sci J 2019, 13(3): 23-31 Back to browse issues page
Effect of Consumption of Honey Containing Bacillus coagulans on Inflammatory and Oxidative Stress Factors in Patients with Diabetic Nephropathy
Navid Mazrouei Arani1 , Zahra Emam-Djomeh2 , Zatollah Asemi 3, Hamid Tavakolipour4 , Reza Sharafati-Chaleshtori5
1- Department of Food Science & Technology, School of Marine Science & Technology, North Tehran Branch, Islamic Azad University
2- Department of Food Science, Technology & Engineering, School of Agricultural Engineering & Technology, University of Tehran
3- Department of Nutrition, Research Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , asemi_z@kums.ac.ir
4- Department of Food Science & Technology, Sabzevar Branch, Islamic Azad University
5- Department of Nutrition, Research Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences
Abstract:   (586 Views)
Background and Objectives: Diabetic nephropathy is one of the dangerous complications of diabetes, which has a relatively high incidence in diabetic patients and causes kidney failure. The aim of this study was to investigate the effect of probiotic honey consumption on inflammatory and oxidative stress indices in patients with diabetic nephropathy.
 
Methods: This randomized, double-blind, controlled clinical trial was conducted on 60 patients with diabetic nephropathy. Patients were randomly divided into two groups including: group consuming probiotic honey containing 108 CFU/g of Bacillus coagulans T11 and group consuming control honey (n=30 each group) 25g/day for 3 months. At baseline and 3 months after consumption of honey samples, fasting blood samples were taken from the patients to determine glycemic index, lipid factors, and inflammatory and oxidative stress indices.
 
Results: In this study, after 3 months of intervention, serum insulin levels (1.2±1.8 vs.-0.1±1.3µIU/ml, p=0.004), HOMA-IR (0.5±0.6 vs. 0.003±0.4, p=0.002), serum high-sensitivity C-reactive protein (hs-CRP) (1.9±2.4 vs.-0.2±2.7mg/l, p=0.01) and malondialdehyde (MDA) levels (-0.1±0.6vs.+0.6±1.0µmol/l, p=0.002) significantly decreased in patients consumed probiotic honey compared to the patients in the control group. Also, quantitative insulin sensitivity check index (QUICKI) score significantly improved
(+0.005±0.009 vs.-0.0007±0.005, p=0.004).
 
Conclusion: The results of this study showed that probiotic honey consumption for 3 months in patients with diabetic nephropathy causes improvement in insulin metabolism, serum hs-CRP level, and plasma MDA, but does not affect other metabolic indices.
Keywords: Bacillus coagulans, honey, Diabetic nephropathies, oxidative stress
Full-Text [PDF 350 kb]   (129 Downloads)    
Type of Study: Original Article | Subject: تغذیه
Received: 2018/11/12 | Accepted: 2019/01/30
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Mazrouei Arani N, Emam-Djomeh Z, Asemi Z, Tavakolipour H, Sharafati-Chaleshtori R. Effect of Consumption of Honey Containing Bacillus coagulans on Inflammatory and Oxidative Stress Factors in Patients with Diabetic Nephropathy. Qom Univ Med Sci J. 2019; 13 (3) :23-31
URL: http://journal.muq.ac.ir/article-1-2306-en.html


Volume 13, Issue 3 (May 2019) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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