[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 11 (January 2015) ::
Qom Univ Med Sci J 2015, 9(11): 12-21 Back to browse issues page
Protective Effect of Royal Jelly against Phenylhydrazine-induced Histological Injuries of Small Intestine of Mice: Morphometric Analyses
Hojat Anbara1, Ali Shalizar Jalali 2, Rasoul Shahrooz1, Mazdak Razi1
1- Urmia University
2- Urmia University , ali_shalizar@yahoo.com
Abstract:   (3803 Views)

Background and Objectives: Phenylhydrazine (PHZ), as a known hemolytic agent, causes toxicity in different tissues at various levels. The aim of the current study was to examine the possible protective effects of royal jelly (RJ) against PHZ-induced histological injuries of small intestine in mice.   Methods: In this experimental study, adult male mice were randomly divided into four groups of 8 mice each. PHZ was administered intraperitoneally to two groups of mice (at a dose of 60mg/kg) every 48 hours for 35 days. One of the groups received RJ (100mg/kg) orally 4 hours before PHZ administration. The third group only received RJ, and the forth group was considered as control. Twenty-four hours after the last treatment, different segments of small intestine were dissected out, then histological sections were prepared and quantitative morphometric assessments were performed. To compare the groups, one-way ANOVA and multiple comparative Tukey tests were used. The significance level was considered to be p<0.05.   Results: In this study, PHZ caused significant decreases in depth of duodenal crypts, distribution rate of the goblet cells in ileal villi, width of duodenal and jejunal villi, and height of villi in all three segments of small intestine. Co-administration of RJ partially improved the changes in the above parameters.   Conclusion: From results of this study, it seems that RJ as a free radical scavenger could reduce PHZ-induced intestinal toxicity in mouse.

Keywords: Royal Jelly, Phenylhydrazine, Intestine, Small, Mice
Full-Text [PDF 1204 kb]   (1166 Downloads)    
Type of Study: Original Article | Subject: داخلی
Received: 2016/02/13 | Accepted: 2016/02/17 | Published: 2016/02/17
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Anbara H, Shalizar Jalali A, Shahrooz R, Razi M. Protective Effect of Royal Jelly against Phenylhydrazine-induced Histological Injuries of Small Intestine of Mice: Morphometric Analyses. Qom Univ Med Sci J. 2015; 9 (11) :12-21
URL: http://journal.muq.ac.ir/article-1-245-en.html

Volume 9, Issue 11 (January 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.2 seconds with 32 queries by YEKTAWEB 3879