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Qom Univ Med Sci J 2020, 14(1): 51-60 Back to browse issues page
The Effects of Liraglutide on In Vitro Fertilization in Mice Following Experimental Diabetes
Rafieh Khalily1 , Shapour Hasanzadeh 2, Ali Shalizar Jalali1 , Rasoul Shahrooze1 , Ggolamreza Nagafi3 , Mehdi Imani4
1- Department of Histology and Embryology, School of Veterinary Medicine, Urmia University
2- Department of Histology and Embryology, School of Veterinary Medicine, Urmia University , s.hasanzadeh@urmia.ac.ir
3- Department of Anatomy and Embryology, School of Veterinary Medicine, Urmia University
4- Department of Biochemistry, School of Veterinary Medicine, Urmia University
Abstract:   (72 Views)
Background and Objectives: Diabetes mellitus has adverse effects on reproductive system. Antidiabetic drugs are likely to develop impairment of fertility. In this regard, the present study was conducted to investigate the adverse effects of antidiabetic drug liraglutide on in vitro fertilization.
 
Methods: A total of 48 adult female mice, were divided into 6 groups of 8 each, as follows: control group that did not receive the drug; non-diabetic group received liraglutide at a dose of 1.2 mg/kg BW; the non-diabetic group that was given liraglutide at a dose of 1.8 mg/kg BW; diabetic group that did not received liraglutide; diabetic group that received liraglutide at a dose of 1.2 mg/kg BW; and diabetic group that received that was given liraglutide at the dose of 1.8 mg/kg BW. Liraglutide was daily injected through subcutaneous route. After 35 days of treatment, the fertility potentials of the retrieved oocytes, was evaluated. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
 
Results: In the diabetic group, a significant ­decrease (p < 0.05),­ were observed in the number of oocytes, percentages of fertilization, percentages of two-cell, four-cell, morula, blastocysts, and hatched embryos compared to the control group. In both diabetic groups receiving the drug, there was a decrease in the aforementioned parameters, but compared to the untreated diabetic group, there was an increase in these parameters.
 
Conclusion: The results revealed that administration of liraglutide in diabetic mice improved fertility and increased the percentage of fertility and Embryos.
 
Keywords: Diabetes Mellitus, Experimental, Fertilization in Vitro, Liraglutide, Mice
Full-Text [PDF 932 kb]   (46 Downloads)    
Type of Study: Original Article | Subject: بافت شناسی و جنین شناسی
Received: 2019/10/6 | Accepted: 2020/02/9
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Khalily R, Hasanzadeh S, Shalizar Jalali A, shahrooze R, Nagafi G, Imani M. The Effects of Liraglutide on In Vitro Fertilization in Mice Following Experimental Diabetes. Qom Univ Med Sci J. 2020; 14 (1) :51-60
URL: http://journal.muq.ac.ir/article-1-2619-en.html


Volume 14, Issue 1 (March 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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