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Qom Univ Med Sci J 2016, 9(12): 1-7 Back to browse issues page
The Effect of Bisphenol A on Liver Tissue Structure and Liver Enzymes
Ozra Rahimi 1, Farah Farokhi2, Seyed Mahdi Banan Khojasteh2
1- University of Urmia , baharan1234@yahoo.com
2- University of Urmia
Abstract:   (4692 Views)

Background and Objectives: Bisphenol A (BPA) is one of the chemical materials, which is used as monomer of epoxy resins and polycarbonate plastics. The present study was performed with the purpose of determining the effect of A on liver enzymes level and liver tissue structure.

Methods: In this experimental study 40 male rats were divided into 4 groups of 10 each: The control group received olive oil at a dose of 1μg/kg bw; group II received BPA at 10μg/kg bw; group III received BPA at 50μg/kg bw; and group IV received BPA at 100μg/kg bw). The groups were administered BPA intraperitoneally for 15 days. At the end, the rats were anesthetized and after extraction of serum, their liver were removed for examination of liver enzymes and evaluated by light microscopy after H&E staining.

Results: The doses of 10 and 50μg/kg bw of BPA had no significant effect on ALT enzyme and 10μg/kg bw had no significant effect on AST enzyme (p>0.05), while BPA at dose of 100 and doses 50 and 100μg/kg bw had significant effects on ALT and AST, respectively, and increased their serum concentration. BPA only at dose of 100μg/kg bw caused inflammation and vacuolization in liver tissue, and its low concentrations had no significant effect on the liver tissue.

Conclusion: The results indicated that low concentrations of BPA had no significant effect on liver tissue and enzymes, but its increased concentration can cause damage to liver tissue and increase the serum levels of liver enzymes.

Keywords: Liver, Inflammation, Bisphenol A
Full-Text [PDF 914 kb]   (2199 Downloads)    
Type of Study: Original Article | Subject: داخلی
Received: 2016/02/18 | Accepted: 2016/02/18 | Published: 2016/02/18
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Rahimi O, Farokhi F, Banan Khojasteh S M. The Effect of Bisphenol A on Liver Tissue Structure and Liver Enzymes. Qom Univ Med Sci J. 2016; 9 (12) :1-7
URL: http://journal.muq.ac.ir/article-1-271-en.html

Volume 9, Issue 12 (February 2016 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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