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Qom Univ Med Sci J 2020, 14(7): 69-78 Back to browse issues page
Prophylactic Effects of Mouthwashes on COVID-19 and its Family Viruses: A Systematic Review
Reza Mottaghi1 , Elaheh Mianeh saz 2
1- Department of Oral and Maxillofacial Surgery, Student Research Center, School of Dentistry, Kashan University of Medical Sciences
2- Clinical Research Support Unit, Shahid Beheshti Hospital, Kashan University of Medical Sciences , ‏‪elaheh.mianehsaz@gmail.com‬‏
Abstract:   (2138 Views)
Background and Objectives: One of the most important ways that coronavirus disease 2019 (COVID-19) is transmitted is through respiratory droplets and contact of person to person. Angiotensin-converting enzyme 2 is one of the receptors of this virus, which is abundant in the oral cavity, especially on the epithelial cells of the tongue. By joining to its receptor in the mouth, the virus can infect an individual and transmit the disease to other individuals. Mouthwashes are among the techniques used for the improvement of oral hygiene and reduction of gingivitis and periodontitis. Moreover, some of them have antiviral and antibacterial properties. The purpose of this study was to review the articles related to effective mouthwashes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (as the causative agent of COVID-19) and its family viruses.
 
Methods: This study was a quick review based on the PRISMA guidelines. The databases, such as PubMed, Scopus, Web of Science, and Google Scholar, were searched using relevant keywords. There were no search restrictions on the date, publication type, and language. Totally, 47 articles were identified in this regard, and finally considering the inclusion criteria 9 articles were extracted and examined based on the study objectives.
 
Results: Out of nine articles, six and two studies were performed in vitro and in vivo, respectively. The results of in vitro studies showed a positive effect of betadine mouthwash in reducing the load of coronaviruses; however, chlorhexidine had no significant effect in this regard. In two in vivo articles, researchers evaluated the effects of these two mouthwashes on SARS-CoV-2. Based on their findings, both mouthwashes had positive effects on decreasing the load of this virus.
 
Conclusion: The use of betadine and chlorhexidine mouthwashes results in reducing the load of SARS-CoV-2. In addition, the two mouthwashes can play a role in the prevention of this disease by the inhibition of its transmission through saliva and oral cavity.
Keywords: COVID-19, Coronavirus, Mouthwashes, Prevention and control
Full-Text [PDF 675 kb]   (622 Downloads)    
Type of Study: Review Article | Subject: دندانپزشکی
Received: 2020/08/13 | Accepted: 2020/09/13 | Published: 2020/10/1
References
1. 1. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020;395(10223):470-3. PMID: 31986257 [DOI:10.1016/S0140-6736(20)30185-9]
2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497-506. PMID: 31986264 [DOI:10.1016/S0140-6736(20)30183-5]
3. Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395(10223):514-23. PMID: 31986261 [DOI:10.1016/S0140-6736(20)30154-9]
4. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579(7798):270-3. PMID: 32015507
5. Kruse RL. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. F1000Res 2020;9:72. PMID: 32117569 [DOI:10.12688/f1000research.22211.2]
6. Li F. Structure, function, and evolution of coronavirus spike proteins. Ann Rev Virol 2016;3(1):237-61. PMID: 27578435 [DOI:10.1146/annurev-virology-110615-042301]
7. Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses 2020;12(2):135. PMID: 31991541 [DOI:10.3390/v12020135]
8. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci 2020;12(1):9. PMID: 32127517 [DOI:10.1038/s41368-020-0075-9]
9. Anderson EL, Turnham P, Griffin JR, Clarke CC. Consideration of the aerosol transmission for COVID‐19 and public health. Risk Anal 2020;40(5):902-7. PMID: 32356927 [DOI:10.1111/risa.13500]
10. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003;426(6965):450-4. PMID: 14647384 [DOI:10.1038/nature02145]
11. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 2020;14(2):185-92. PMID: 32170560 [DOI:10.1007/s11684-020-0754-0]
12. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020;12(1):8. PMID: 32094336 [DOI:10.1038/s41368-020-0074-x]
13. Pires JR, Rossa Junior C, Pizzolitto AC. In vitro antimicrobial efficiency of a mouthwash containing triclosan/gantrez and sodium bicarbonate. Braz Oral Res 2007;21(4):342-7. PMID: 18060262 [DOI:10.1590/S1806-83242007000400011]
14. FDI Commission. Mouthrinses and periodontal disease. Int Dent J 2002;52(5):346-52. PMID: 12418603 [DOI:10.1002/j.1875-595X.2002.tb00882.x]
15. Haffajee AD, Yaskell T, Socransky SS. Antimicrobial effectiveness of an herbal mouthrinse compared with an essential oil and a chlorhexidine mouthrinse. J Am Dent Assoc 2008;139(5):606-11. PMID: 18451378 [DOI:10.14219/jada.archive.2008.0222]
16. Yan Y, Chen H, Chen L, Cheng B, Diao P, Dong L, et al. Consensus of Chinese experts on protection of skin and mucous membrane barrier for health‐care workers fighting against coronavirus disease 2019. Dermatol Ther 2020;13:e13310. PMID: 32170800
17. Yoon JG, Yoon J, Song JY, Yoon SY, Lim CS, Seong H, et al. Clinical significance of a high SARS-CoV-2 viral load in the Saliva. J Korean Med Sci 2020;35(20):e195. PMID: 32449329 [DOI:10.3346/jkms.2020.35.e195]
18. Kawana R, Kitamura T, Nakagomi O, Matsumoto I, Arita M, Yoshihara N, et al. Inactivation of human viruses by povidone-iodine in comparison with other antiseptics. Dermatology 1997;195(Suppl 2):29-35. Link [DOI:10.1159/000246027]
19. Eggers M, Koburger-Janssen T, Eickmann M, Zorn J. In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens. Infect Dis Ther 2018;7(2):249-59. PMID: 29633177 [DOI:10.1007/s40121-018-0200-7]
20. Schünemann HJ, Moja L. Reviews: rapid! rapid! rapid!… and systematic. Syst Rev 2015;4:4. Link [DOI:10.1186/2046-4053-4-4]
21. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010;8(5):336-41. Link [DOI:10.1016/j.ijsu.2010.02.007]
22. Wood A, Payne D. The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses. J Hosp Infect 1998;38(4):283-95. PMID: 9602977 [DOI:10.1016/S0195-6701(98)90077-9]
23. Eggers M, Eickmann M, Zorn J. Rapid and effective virucidal activity of povidone-iodine products against Middle East respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus Ankara (MVA). Infect Dis Ther 2015;4(4):491-501. PMID: 26416214 [DOI:10.1007/s40121-015-0091-9]
24. Martínez Lamas L, Diz Dios P, Pérez Rodríguez M, Del Campo P, Cabrera Alvargonzalez J, López Domínguez A, et al. Is povidone‐iodine mouthwash effective against SARS‐CoV‐2? First in vivo tests. Oral Dis 2020;In Press. PMID: 32615642 [DOI:10.1111/odi.13526]
25. Anderson DE, Sivalingam V, Kang AEZ, Ananthanarayanan A, Arumugam H, Jenkins TM, et al. Povidone-iodine demonstrates rapid in-vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease. Infect Dis Ther 2020;9(3):669-75. PMID: 32643111 [DOI:10.1007/s40121-020-00316-3]
26. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Rapid in‐vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) using povidone‐iodine oral antiseptic rinse. J Prosthodont 2020;29(6):529-33. PMID: 32511851 [DOI:10.1111/jopr.13209]
27. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of in vitro inactivation of SARS-CoV‐2 with hydrogen peroxide and povidone‐iodine oral antiseptic rinses. J Prosthodont 2020;In Press. PMID: 32608097 [DOI:10.1111/jopr.13220]
28. Liang B, Yuan X, Wei G, Wang W, Zhang M, Peng H, et al. In-vivo toxicity studies and in-vitro inactivation of SARS-CoV-2 by povidone-iodine in-situ gel forming formulations. BioRxiv 2020;In Press. PMID: 32511395 [DOI:10.1101/2020.05.18.103184]
29. Listerine. PubChem. National Library of Medicine. Available at: URL: https://pubchem.ncbi.nlm.nih.gov/
30. compound/Listerine; 2020. Link
31. Kato T, Iijima H, Ishihara K, Kaneko T, Hirai K, Naito Y, et al. Antibacterial effects of Listerine on oral bacteria. Bull Tokyo Dent Coll 1990;31(4):301-7. PMID: 2133450
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Mottaghi R, Mianeh saz E. Prophylactic Effects of Mouthwashes on COVID-19 and its Family Viruses: A Systematic Review. Qom Univ Med Sci J. 2020; 14 (7) :69-78
URL: http://journal.muq.ac.ir/article-1-2898-en.html


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Volume 14, Issue 7 (September 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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