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Qom Univ Med Sci J 2020, 14(10): 25-33 Back to browse issues page
Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats
Bahareh Seifi Nahavandi1 , Parichehreh Yaghmaei 2, Shahin Ahmadian3 , Azadeh Ebrahim-Habibi4 , Maryam Ghobeh1
1- Department of Biology, Science and Research Branch, Islamic Azad University
2- Department of Biology, Science and Research Branch, Islamic Azad University , yaghmaei_p@srbiau.ac.ir
3- Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran
4- Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences
Abstract:   (69 Views)
Background and Objectives: Alzheimerchr('39')s disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of terpinolene and physical activity on memory and learning in a model of Alzheimerchr('39')s rats.
 
Methods: Bilateral injection of AB1-42 was administered to the hippocampus of the male rats to create the model of Alzheimerchr('39')s disease. The assigned groups included control (-), sham, exercise, control (+), Alzheimerchr('39')s+distilled water, Alzheimerchr('39')s+exercise, Alzheimerchr('39')s+terpinolene (treatment), Alzheimerchr('39')s+terpinolene (prevention), and Alzheimerchr('39')s+terpinolene+exercise. Superoxide dismutase (SOD), Malondialdehyde (MDA) level, shuttle box behavioral test, as well as neurogenesis and amyloid plaques were assessed in this study. The data were statistically analyzed using one-way ANOVA.
 
Results: The SOD activity and neurogenesis levels decreased significantly in the control (+) group, compared to control groups of the behavioral test. However, the MDA level and plaque increased significantly (P<0.05). Terpinolene intake and exercise caused a significant increase in neurogenesis, a significant decrease in plaques, and significant changes in biochemical and behavioral parameters (P<0.05).
 
Conclusion: Based on the results of this study and previous reports on the antioxidant and anti-inflammatory effects of terpinolene and exercise, it seems that this combination along with exercise can improve memory complications and disorders.
 
Keywords: Alzheimer’s disease, Amyloid beta-peptides, Exercise, Rats, Terpinolene.
Full-Text [PDF 1033 kb]   (18 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2020/09/26 | Accepted: 2021/01/9 | Published: 2020/12/30
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Seifi Nahavandi B, Yaghmaei P, Ahmadian S, Ebrahim-Habibi A, Ghobeh M. Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats. Qom Univ Med Sci J. 2020; 14 (10) :25-33
URL: http://journal.muq.ac.ir/article-1-2934-en.html


Volume 14, Issue 10 (December 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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