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:: Volume 10, Number 11 (January 2017) ::
Qom Univ Med Sci J 2017, 10(11): 25-33 Back to browse issues page
The Effects of Hydroalcoholic Extract of Achillea millefolium on In Vitro Fertilization (IVF) and Embryonic Development Process in Mice
Neda Asliranifam *1, Shapour Hasanzadeh2, Golam Reza Najafi Tazekand3
1- Ph.D Histology Young Researchers and Elite Club , n.iranifam@yahoo.com
2- Associate professor Urmia University
3- Assistant Professor Urmia University
Abstract:   (460 Views)

Background and Objectives: Achillea millefolium Inflorescences (AMI) is one of the oldest and most well-known medicinal plants with potential antioxidant properties. This study aimed to investigate the effects of three different doses of hydroalcoholic extract of AMI on in vitro fertilization and embryonic development process in mice.

Methods: Twenty-four male white laboratory NMRI mice were randomly divided into 4 groups: Group 1 received normal saline (0.1 ml/kg); group 2, 3, and 4 received hydroalcoholic extract of AMI at doses of 75, 150, and 300mg/kg, respectively. Treatment were continued for 35 days. At the end, the mice were euthanized by cervical dislocation, Cauda Epididymis were used to collect sperms, and rate of in vitro fertilization and embryonic development were examined in all groups. Data analysis was performed using one-way ANOVA and Tukey post-hoc tests.

Results: In the groups receiving low and medium doses of AMI extract, fertilization rate and the number of blastocysts increased and the number of arrested embryos was reduced, which was not significant compared to the control group. But in the group receiving high dose of the extract, fertilization rate and the number of blastocysts decreased (p<0.05) and the number of arrested embryos significantly increased compared to the control group (p<0.01).

Conclusion: According to the results of this study, hydroalcoholic extract of AMI has a dose-dependent manner, so that at low and medium doses had no significant effect, but at high dose reduced in vitro fertilization and embryos development.

Keywords: Achillea, Fertilization in vitro, Mice
Full-Text [PDF 439 kb]   (328 Downloads)    
Type of Study: Original Article | Subject: آناتومی
Received: 2016/02/25 | Accepted: 2016/04/10 | Published: 2017/01/24
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Asliranifam N, Hasanzadeh S, Najafi Tazekand G R. The Effects of Hydroalcoholic Extract of Achillea millefolium on In Vitro Fertilization (IVF) and Embryonic Development Process in Mice. Qom Univ Med Sci J . 2017; 10 (11) :25-33
URL: http://journal.muq.ac.ir/article-1-333-en.html
Volume 10, Number 11 (January 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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