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:: Volume 3, Issue 3 (6-2009) ::
Qom Univ Med Sci J 2009, 3(3): 31-36 Back to browse issues page
Evaluation of Discrimination Indices Validity for Screening of β-Thalassemia Trait
A Ahmadi1, R Mirzaee Khalilabadi 1, M Noorozi2, N Cohan3, M Ramzi3
1- Tehran University of Medical Sciences
2- Qom University of Medical Sciences,
3- hiraz University of Medical Sciences
Abstract:   (2199 Views)

Background and Objectives: β-thalassemia trait (β-TT) and iron deficiency anemia (IDA) are the most common forms of microcytic anemia. Screening of β-thalassemia trait is important for medical counseling before marriage and preventing β-thalassemia major birth results. The most common problem in screening b-TT is differentiating it from IDA. The aim of this study was to define the sensitivity, specificity, and predictive values of some discrimination indices for screening of β-TT in a sample of such patients. Methods: A total of 82 patients with microcytic anemia (MCV< 80 fl) were selected from Namazi Hospital, Shiraz, Iran, and 9 discrimination indices were calculated for them. The patients were divided intotwo groups: 42 patients with β-TT and 40 patients with IDA. The sensitivity, specificity, positive and negative predictive values and Youden , s index of each discrimination index were calculated for screening β-TT. Results: None of the discrimination indices showed 100% of sensitivity and specificity. But the Shin and Lal index, RDW index and RBC count showed the highest and valuable value for screening β-TT. Conclusion: Some discrimination indices like Shin and Lal index, RDW index and RBC index are valuable indices in screening β-TT.

Keywords: Beta- Thalassemia, Anemia, Iron Deficiency
Full-Text [PDF 203 kb]   (3291 Downloads)    
Type of Study: Original Article |
Received: 2016/02/13 | Accepted: 2016/02/22 | Published: 2016/02/22
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Ahmadi A, Mirzaee Khalilabadi R, Noorozi M, Cohan N, Ramzi M. Evaluation of Discrimination Indices Validity for Screening of β-Thalassemia Trait. Qom Univ Med Sci J. 2009; 3 (3) :31-36
URL: http://journal.muq.ac.ir/article-1-42-en.html


Volume 3, Issue 3 (6-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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