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:: Volume 10, Issue 4 (June 2016 2016) ::
Qom Univ Med Sci J 2016, 10(4): 1-9 Back to browse issues page
The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats
Hamid Marefati 1, Soheil Aminizadeh * 2, Hamid Najafipour 3, Shahriar Dabiri 4, Beydollah Shahouzehi 4
1- Kerman University of Medical Sciences
2- Shahid Bahonar University of Kerman , s-aminizadeh@phdstu.scu.ac.ir
3- Physiology Research Center
4- Kerman University of Medical Sciences, Kerman
Abstract:   (2470 Views)

Background and Objectives: Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats.

Methods: In this study, 16 adult male Wistar rats were randomly divided into two groups of 8 mice: Control and moderate-intensity interval training (MIIT). At the end of 16th week of the training, all rats intraperitoneally received isoproterenol (dose, 85mg/kg) for 2 consecutive days, then cardiac function parameters [heart rate, diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular±dp/dt max], Biochemical indicators of tissue damage (heart tissue CTnI and TNF-α) were measured; also, the extent of heart tissue damage was evaluated by histopathological examination. The data were analyzed using nonparametric Mann-Whitney test and independent t-test. The significance level was considered as p≤0.05.

Results: No significant differences were seen between the groups in any of the cardiac function parameters [HR (p<0.130), SBP (p<0.48) and DBP (p<0.72)]. However, other cardiac function parameters including left ventricular±dp/dt max in the exercise group was significantly different from the control group (p<0.01). The heart tissue CTnI in the exercise group was significantly higher than the control group (p<0.009). The heart tissue TNF-α in the exercise group was significantly lower than the control group (p<0.029). Histopathological examinations showed the positive effect of exercise protocol on the reduction of tissue damage in ischemic (p<0.003).

Conclusion: The results showed that moderate-intensity interval training has protective effects against cardiac damage caused by injection of isoproterenol.

Keywords: Cardiac function test, Isoproterenol, Myocardial reperfusion injury, Exercise.
Full-Text [PDF 693 kb]   (2530 Downloads)    
Type of Study: Original Article |
Received: 2016/06/15 | Accepted: 2016/06/15 | Published: 2016/06/15
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Marefati H, Aminizadeh S, Najafipour H, Dabiri S, Shahouzehi B. The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats. Qom Univ Med Sci J . 2016; 10 (4) :1-9
URL: http://journal.muq.ac.ir/article-1-923-en.html


Volume 10, Issue 4 (June 2016 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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