[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Number 2 ( April 2017 2017) ::
Qom Univ Med Sci J 2017, 11(2): 1-9 Back to browse issues page
Immunological Effects of Chitosan Nanoparticles on Breast Cancer Cells in Animal Model
Neda Soleimani *1, Ashraf Mohabati Mobarez2
1- Shahid Beheshti University , soleimani_neda86@yahoo.com
2- associate professor Tarbiat Modares University
Abstract:   (561 Views)

Background and Objectives: Cancer is one of the leading causes of death around the world with a very high degree of mortality. Conventional therapies by cytotoxic drugs have high levels of side-effects for patient. Chitosan is a biocompatible and biodegradable compound. Thus, according to the minimum systemic toxicity for peptide and drug delivery, it is considered in applied programs. In this study, the Immunological effect of chitosan nanoparticles, was investigated on breast cancer cells in animal model.

Methods: In this experimental model, chitosan nanoparticles were synthesized. The size and electrical charge were determined using DLS apparatus and SEM. After creation of tumor model in female BALB/c mice. Injections in the test and control groups, were performed intraperitoneally. IL-4 and IFN-γ were assayed using ELISA method to investigate the immunomodulatory effects of the nanoparticles.

Results: Electric charge and size of the nanoparticles were determined and confirmed to be +11 mv and 200 nm, respectively. The nanoparticle-treated group produced large amounts of IFN-γ (213 pg/ml), while IL-4 level decreased (p<0.5).

Conclusion: These nanoparticles has the potential to shift immune responses from a Th2 to Th1 through IFN-γ production. Hence, these nanoparticles may be an appropriate and effective candidate for cancer therapy.

Keywords: Neoplasms, Nanoparticles, Immune system
Full-Text [PDF 5620 kb]   (468 Downloads)    
Type of Study: Original Article | Subject: علوم پایه
Received: 2016/04/10 | Accepted: 2016/04/24 | Published: 2017/04/18
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soleimani N, Mohabati Mobarez A. Immunological Effects of Chitosan Nanoparticles on Breast Cancer Cells in Animal Model. Qom Univ Med Sci J . 2017; 11 (2) :1-9
URL: http://journal.muq.ac.ir/article-1-667-en.html
Volume 11, Number 2 ( April 2017 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.16 seconds with 797 queries by yektaweb 3501