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Qom Univ Med Sci J 2017, 11(3): 83-94 Back to browse issues page
RNA Interference: A Promising Tool in the Control of Important Vector Born Diseases Zika, Dengue Fever, and Malaria
Jalil Nejati1, Mona Koosha1, Mohammad Ali Oshaghi 2
1- Tehran University of Medical Siences
2- Tehran University of Medical Siences , moshaghi@sina.tums.ac.ir
Abstract:   (2537 Views)

Background and Objectives: RNA interference is a process, in which a molecule of double-stranded RNA prevents the expression of a particular gene and leads to its silencing. Application of this technology in the control of disease-carrying insects is rising in agriculture and medical sciences. Also, its application in control of insect-borne diseases could be considered as a new, important, and effective approach. In this article, it was attempted to study the mechanisms of RNA interference, routs of its delivery to insects, as well as its application in genetic control of disease vector insects.

Methods: In this study, 71 indexed articles in databases, such as Pubmed, SID, Scopus, Science direct, and Google scholar, were used.

Results: dsRNA could be delivered to insect body through three routes of oral, injection, and Impregnation. The mechanism of dsRNA entrance into the cells has considerable effect on the success and applicability of this technique. Identification of host-parasite relationship in the insect body is one of the important applications of RNAi in medical entomology.

Conclusion: Although, there is a considerable number of researches on RNAi in the agricultural pests field, studies on insect vectors of human diseases have been mostly in-vivo. However, application of RNAi is suggested as a new, safe and applicable approach, alone or along with other methods. Certainly, further researches in this field can pave the way for enforcement measures in the control of disease vectors, especially Zika, dengue fever, and malaria in the not so distant future.

Keywords: RNA interference, Gene expression, entomology
Full-Text [PDF 556 kb]   (1191 Downloads)    
Type of Study: Review Article | Subject: سلولی و مولکولی
Received: 2016/03/27 | Accepted: 2016/04/30 | Published: 2017/05/20
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Nejati J, Koosha M, Oshaghi M A. RNA Interference: A Promising Tool in the Control of Important Vector Born Diseases Zika, Dengue Fever, and Malaria. Qom Univ Med Sci J. 2017; 11 (3) :83-94
URL: http://journal.muq.ac.ir/article-1-470-en.html

Volume 11, Issue 3 (May 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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