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Qom Univ Med Sci J 2017, 11(10): 64-69 Back to browse issues page
Investigation of the Association between GFPT2 Gene Polymorphism and Risk of Type 2 Diabetes
Soyar Sari *
Department of Molecular & Cellular Sciences, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran. , sari.soyar@gmail.com
Abstract:   (1908 Views)
Background and Objectives: Type 2 diabetes is one of the most common metabolic diseases and a complex disorder with a strong genetic predisposition, which significantly affects mortality. A series of factors, such as environmental factors and genetic background are involved in the disease. Recently, a new gene associated with type 2 diabetes has been discovered, which is called GFPT2 and is located on the long arm of chromosome 5. Various mutations can alter GFPT2 function and provide risk for diabetes. In this study, the association of GFPT2 gene polymorphism and the risk of type 2 diabetes, was investigated.
Methods: In this case-control study, 150 type 2 diabetic patients and 150 healthy individuals, were randomly selected from the research population. GFPT2 gene polymorphism was investigated using PCR-RFLP method. Chi-square test was used to determine the balance or imbalance in the two studied groups, the association between polymorphism and incidence of type 2 diabetes.
Results: In this study, a significant difference was observed in the genotype distribution of GFPT2 gene in patients with type 2 diabetes in comparison with the healthy subjects [p= 0.041, (odds ratio: 2.81 (95%CI: 1.02-5.09)].
Conclusion: The results of the present study indicated that there is evidence that there is an association between genetic variant of GFPT2 gene and the incidence of type 2 diabetes. Therefore, further studies are necessary to evaluate the importance of genetic variant in different populations.
Keywords: Human GFPT2 protein, Polymorphism, Genetic, DNA restriction enzymes, Diabetes mellitus.
Full-Text [PDF 382 kb]   (416 Downloads)    
Type of Study: Original Article | Subject: سلولی و مولکولی
Received: 2016/09/12 | Accepted: 2016/10/25 | Published: 2017/12/18
* Corresponding Author Address: sari.soyar@gmail.com
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Sari S. Investigation of the Association between GFPT2 Gene Polymorphism and Risk of Type 2 Diabetes . Qom Univ Med Sci J. 2017; 11 (10) :64-69
URL: http://journal.muq.ac.ir/article-1-1161-en.html

Volume 11, Issue 10 (December 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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