:: Volume 12, Issue 2 (April 2018) ::
Qom Univ Med Sci J 2018, 12(2): 28-34 Back to browse issues page
An Association Study of rs2829803 Polymorphism in miRNA-155 with Multiple Sclerosis in Patients Referred to Farshchian Hospital of Hamadan City, (Iran)
Sanaz Abolfathirad * 1, Soyar Sari 1 , Reza Mirfakhraie 2
1- 1Department of Cellular & Molecular Sciences, Faculty of Advanced Science & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (660 Views)
Background and Objectives: Multiple sclerosis is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and polymorphisms have been known to be associated with it. In this study, the correlation between polymorphism of rs2829803 in miR-155 and multiple sclerosis, was investigated in the patients referred to Farshchian Hospital of Hamadan City.
Methods: In this case-control study, 130 patients (29% male, 71% female) with multiple sclerosis (age range, 17-69 years) and 150 healthy subjects (38% male, 62% female) (age range, 19-63 years), were selected as the control group. Genotyping was performed by Tetra-ARMS-PCR method.
Results: A significant difference was observed in the genotypic distribution of miR-155 rs2829803 in dominant form (OR: 0.33, 95% CI: 1.19-0.58) (p=0.0001) and heterozygote (OR: 1.92, 95% CI:1.17-3.16) (p=0.01) in patients compared to the healthy subjects.
Conclusion: In line with previous studies on the relationship between miR-155 polymorphism (rs2829803) and multiple sclerosis disease, the results of this study confirmed the association of this polymorphism with increased risk of developing the disease.
Keywords: Multiple sclerosis, MicroRNAs, Polymorphism, Genetic.
Full-Text [PDF 494 kb]   (269 Downloads)    
Type of Study: Original Article | Subject: سلولی و مولکولی
Received: 2016/12/26 | Accepted: 2017/02/7 | Published: 2018/04/15

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Volume 12, Issue 2 (April 2018) Back to browse issues page