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Qom Univ Med Sci J 2015, 9(10): 7-1 Back to browse issues page
Effect of Tetracycline and Vitamin E on Spatial Memory, Learning, and Depression in Wistar Rats
Neda Naderi *1, Mehdi Mohammadzadeh2, Samad Zare2, Minoo Elkhanipoor2
1- Faculty of Sciences, Urmia University , naderineda86@yahoo.com
2- Faculty of Sciences, Urmia University
Abstract:   (3904 Views)

Background and Objectives: Tetracyclines are antibiotics that are widely used. Tetracycline, easily passes the blood-brain barrier and protects the nervous system due to its specific chemical structure. Vitamin E is one of the fat-soluble vitamins. This vitamin helps prevent the progression of Alzheimer's disease. The purpose of the present study is to investigate the effects of tetracycline and vitamin E on spatial memory, learning, and depression.   Methods: In this experimental study, 21 male Wistar rats were randomly divided into 3 groups of 7 each. The effect of tetracycline and vitamin E on memory, learning, and depression was investigated using 8-arm radial maze and elevated plus maze. Data were analyzed by one-way ANOVA and Tukey's statistical tests. Statistical significance level was considered p<0.05.   Results: After 21 days of treatment, it was shown that tetracycline antibiotic has a significant effect on memory. Also Vitamin E significantly reduced depression and its protective effect decreased the adverse effect of tetracycline. In the treatment group, vitamin E along with tetracycline had a significant effect on memory loss.   Conclusion: The results of the present study indicated that use of vitamin E can reduce depression by its antioxidant and protective effects. Tetracycline also significantly increases memory. Therefore, according to the results, it is suggested that tetracycline be used along with vitamin E to reduce negative effects of the drug.

Keywords: Tetracycline, Vitamin E, Memory, Learning, Depression, rats
Full-Text [PDF 350 kb]   (1294 Downloads)    
Type of Study: Original Article | Subject: داخلی
Received: 2016/02/13 | Accepted: 2016/02/20 | Published: 2016/02/20
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Naderi N, Mohammadzadeh M, Zare S, Elkhanipoor M. Effect of Tetracycline and Vitamin E on Spatial Memory, Learning, and Depression in Wistar Rats. Qom Univ Med Sci J. 2015; 9 (10) :7-1
URL: http://journal.muq.ac.ir/article-1-240-en.html

Volume 9, Issue 10 (12-2015) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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