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:: Volume 11, Number 4 ( June 2017) ::
Back to browse issues page Qom Univ Med Sci J 2017, 11(4): 20-31
The Effects of 6 Weeks of Endurance Training and Consumption of Different Doses of Boldenone on Hematological Factors and Spleen Structure Changes in Male Wistar Rats
Asieh Abbassi Daloii *1, Seyed Javad Ziaolhagh2, Seyed Javad Ziaolhagh3, Mojde Fazelniya3
1- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran , abbasi.daloii@gmail.com
2- 2Department of Exercise Physiology, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
3- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Abstract:   (75 Views)

Background and Objectives: Regardless of how many periods and how long the androgenic-anabolic steroids have been used, they can cause side effects. The objective of this study was to investigate the effect a 6-week endurance training and using different doses of anabolic steroid boldenone on hematological factors and changes in spleen structure in male Wistar rats.

Methods: In this experimental study, 47 male Wistar rats aged 12 weeks, were randomly divided into 7 groups (control, sham, boldenone-1, boldenone-2, endurance training, endurance training+boldenone-1, endurance training+boldenone-2). Increasing endurance training program was performed at the speed of 10-30m/min (Vo2max, 75-80%) for 6 weeks and 5 days/week. The drug was injected deeply into the quadriceps and hamstring muscles once a week, on an appointed day. After anesthesia and dissection, the spleen was removed. Finally, the selected microscopic sections, were studied using a light microscope after staining with hematoxylin and eosin. Data were analyzed by dependent t-, one-way ANOVA, and post-hoc LSD tests at α<0.05 level.

Results: In this study, boldenone supplementation at different doses led to weight gain, non-significant decrease in spleen weight (p=0.297), increase in white blood cells (p=0.041), and increase in hematocrit level (p=0.017). Also, there was a significant difference between the effect of exercise and boldenone consumption on the extent of damage to white pulp, red pulp, and the spleen sinusoidal space (p=0.001).

Conclusion: The findings of this study showed it is likely that short-term consumption of boldenone have negative effects on the spleen structure, followed by negative changes in hematological factors.

 

Keywords: Endurance training, Boldenone, Hematological factors, Spleen, Rat.
Full-Text [PDF 915 kb]   (82 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی ورزشی
Received: 2016/02/22 | Accepted: 2016/05/29 | Published: 2017/06/13
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Abbassi Daloii A, Ziaolhagh S J, Ziaolhagh S J, Fazelniya M. The Effects of 6 Weeks of Endurance Training and Consumption of Different Doses of Boldenone on Hematological Factors and Spleen Structure Changes in Male Wistar Rats. Qom Univ Med Sci J . 2017; 11 (4) :20-31
URL: http://journal.muq.ac.ir/article-1-312-en.html
Back to browse issues page Volume 11, Number 4 ( June 2017)
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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