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:: Volume 3, Issue 3 (6-2009) ::
Qom Univ Med Sci J 2009, 3(3): 13-18 Back to browse issues page
In vitro Antifungal Activity of Shallot Extract and Its Comparison with Miconazole
MJ Nasiri Kashani 1, M Falahati 1, M Motevalian 1, A Yazdanparast 1, R Fateh * 2
1- Iran University of Medical Sciences
2- Iran University of Medical Sciences , rfateh59@yahoo.com
Abstract:   (1607 Views)

Background and Objectives : Shallots are an important part of the diet of many populations and show some different pharmacological effects in different medical aspects. Some studies have been performed to evaluate the antimicrobial effects of shallots. The objective of this survey was to evaluate its antifungal activities in several fungal species. Methods: In this experimental study, after extracting shallot by soxhlet's procedure, antifungal effects of alcoholic and aqueous extracts of shallot (Allium hirtifolium) against 5 saprophyte species (Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Penicillium gryseogenum and Alternaria) and 2 dermatophyte species (Microsporum canis and Trichophyton mentagrophytes) were evaluated in vitro. Minimum Inhibitory Concentrations (MIC s ) were determined by broth macrodilution method and finally were compared with miconazole. Results: Allium hirtifolium showed antifungal effects against all the tested fungi with MIC ranged between 0.058 to 0.8 mg/ml for alcoholic extract and 0.26 to 3.84 mg/ml for aqueous extract, respectively. Minimum Fungicidal Concentrations (MFC s ) of alcoholic and aqueous extracts ranged between 0.1 to 12.8 mg/ml and 0.6 to 68.26 mg/ml, respectively. Conclusion: This study indicated that shallot crude juice has antifungal activity and looks promising to be an alternatative for chemical antifungal agents that have sometimes serious side effects.

Keywords: : Microbial Sensitivity Test, Minimum Fungicidal Concentration, Saprophyte, Arthrodermataceae
Full-Text [PDF 186 kb]   (1651 Downloads)    
Type of Study: Original Article |
Received: 2016/02/13 | Accepted: 2016/02/22 | Published: 2016/02/22
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Nasiri Kashani M, Falahati M, Motevalian M, Yazdanparast A, Fateh R. In vitro Antifungal Activity of Shallot Extract and Its Comparison with Miconazole. Qom Univ Med Sci J . 2009; 3 (3) :13-18
URL: http://journal.muq.ac.ir/article-1-39-en.html


Volume 3, Issue 3 (6-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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