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:: Volume 8, Issue 5 (11-2014) ::
Qom Univ Med Sci J 2014, 8(5): 40-47 Back to browse issues page
The Effect of Vitamin C Supplementation on Serum levels of Hemoglobin, Hematocrit and Ferritin in Hemodialysis Patients: A Randomized Clinical Trial
Vajihe Biniaz 1, Ali Tayebi * 2, Mahdi Sadeghi Shermeh 1, Abbas Ebadi 1, Eghlim Nemati 1
1- Baqiyatallah University of Medical Sciences
2- Baqiyatallah University of Medical Sciences , tayybiali@gmail.com
Abstract:   (1820 Views)

Background and Objectives:Anemia is one of the common complications of chronic renal failure and vitamin C can improve anemia through releasing iron from ferritin and its transfer from the reticuloendothelial system to transferrin. This study was performedwith the objective ofevaluating the effect ofvitaminCsupplementation on serum levels of hemoglobin, hematocrit, and ferritin in hemodialysis patients.

Methods:In a double-blindclinical trial,178 patients with chronic renal failure were randomly divided into three groups of intervention, control, and witness. In the intervention group, 250 mg vitamin C, 250 mg of vitamin C was injected intravenously at the end of each hemodialysis session three times a week for 8 weeks.In the witness group, same amount of placebo saline was injected at the same time,and no intervention was performed in the control group. Laboratory parameters, including serum levels of hemoglobin, hematocrit, and ferritin were measured at the beginning and end of the intervention. Data analysis was performed by Chi-square and one-way ANOVA. The significance level was considered to be p<0.05.

Results: There were significant differences in serum levels of hemoglobin and hematocrit in the interventiongroup,but, the changes of the serum level of ferritinwere not significant in any of the groups.

Conclusion: The results of this study showed that vitamin C supplementation in hemodialysis patients cansignificantlyincrease the meanserum levels of hemoglobin and hematocrit, however, it cannot significantlychange the serum ferritin level.

Keywords: Renal Insufficiency, Chronic, Renal Dialysis, Anemia, Hemoglobins, Ascorbic Acid, ARandomized Clinical Trial
Full-Text [PDF 492 kb]   (509 Downloads)    
Type of Study: Original Article |
Received: 2016/03/10 | Accepted: 2016/03/10 | Published: 2016/03/10
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Biniaz V, Tayebi A, Sadeghi Shermeh M, Ebadi A, Nemati E. The Effect of Vitamin C Supplementation on Serum levels of Hemoglobin, Hematocrit and Ferritin in Hemodialysis Patients: A Randomized Clinical Trial . Qom Univ Med Sci J. 2014; 8 (5) :40-47
URL: http://journal.muq.ac.ir/article-1-398-en.html


Volume 8, Issue 5 (11-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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