:: Volume 11, Issue 10 (December 2018) ::
Qom Univ Med Sci J 2018, 11(10): 13-20 Back to browse issues page
Effect of Vitamin E on Memory Damage Induced by Streptozotocin in Adult Male Wistar Rats
Fatemeh Hosseinzadeh 1, Akram Eidi * 2, Pejman Mortazavi , Ali Haeri Rohani 1
1- Department of Biology, Science & Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Biology, Science & Research Branch, Islamic Azad University, Tehran, Iran , akram_eidi@yahoo.com
Abstract:   (1012 Views)
Background and Objectives: Vitamin E is a nutrient essential for the body. This vitamin as a natural antioxidant, scavenges free radicals in cell membranes and protects unsaturated fatty acids from lipid peroxidation. In the present study, the effect of vitamin E on neurodegeneration induced by intracerebroventricular (ICV) administration of streptozotocin (STZ), was investigated in mature adult male Wistar rats.
Methods: In this experimental study, the rats were randomly divided into 4 groups of normal control, Alzheimer control rats, and vitamin E (100 and 200mg/kg bw, oral daily) together with STZ. The animals received STZ at a dose of 3μl/cannula, 75mg/ml, ICV, bilaterally, on the 1st and 3rd days. Vitamin E treatment was started 1h before the first dose of STZ and continued for 14 days. Learning and memory behavior was evaluated using passive avoidance test. Data were analyzed by one-factor analysis of variance.
Results: STZ treatment decreased step-through latency and increased the time in the dark compartment. Moreover, vitamin E treatment attenuated these changes.
Conclusion: The results of this research showed that vitamin E treatment significantly improves STZ-induced cognitive impairment. Therefore, vitamin E can provide protection against aging-induced memory deficit and neuronal damage induced by STZ.
Keywords: Memory, Streptozotocin, Vitamin E.
Full-Text [PDF 429 kb]   (241 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2016/04/10 | Accepted: 2016/12/13 | Published: 2017/12/17

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Volume 11, Issue 10 (December 2018) Back to browse issues page