:: Volume 11, Issue 6 (August 2017) ::
Qom Univ Med Sci J 2017, 11(6): 1-9 Back to browse issues page
Effect of 12 Weeks of Treadmill Aerobic Training on Cytochrome c and Caspase-9 gene Expression in Cardiac Muscle of Male Rats
Nasrin Javid Tabrizi 1, Jabbar Bashiri 2, Mohammad Narimani Rad 3
1- MSc Student Islamic Azad University
2- Associate Professor Islamic Azad University , bashiri.jabbar@gmail.com
3- Assistant professor shabestar Branch, Islamic Azad University, shabestar, Iran
Abstract:   (1500 Views)
Background and Objectives: Apoptosis plays an important role in the development of cardiovascular diseases, especially heart failure. Some evidences suggest that exercise training may alter apoptosis-related signaling in somatic tissues such as the myocardium. The purpose of the present study was to determine the effect of 12 weeks of treadmill aerobic training on cytochrome c and caspase-9 gene expression in cardiac muscle of male rats.
Methods: This study was conducted as a two-group experimental design project (animal model) on 16 3-month-old male rats. Animals were randomly divided into two homogeneous groups of aerobic training and control (8 animals each). Animals of the training group underwent an aerobic training program for 12 weeks (75-80% VO2max). Forty-eight hours after the last training session, their hearts were extracted and cytochrome c and caspase-9 genes, were evaluated by RT-PCR. Data were analyzed using independent t-test at the significance level of p<0.05.
Results: Cytochrome c gene expression in the experimental group was significantly higher than the control group (140.62%, p<0.05). The expression of caspase-9 gene, was also significantly higher in the experimental group compared to the control group (333.92%, p<0.05).
Conclusion: Overall, it seems that 2-weeks of aerobic training on treadmill has a significant effect on the increased the expression of key genes of the cardiac mitochondrial apoptosis pathway. However, the underlying mechanisms of these effects are unclear and require further researches.
Keywords: Aerobic exercise, Myocardium, Apoptosis
Full-Text [PDF 562 kb]   (621 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی ورزشی
Received: 2016/05/25 | Accepted: 2016/07/31 | Published: 2017/08/17

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Volume 11, Issue 6 (August 2017) Back to browse issues page