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:: Volume 11, Issue 9 (Novamber 2017) ::
Qom Univ Med Sci J 2017, 11(9): 1-9 Back to browse issues page
The effect of high-intensity Interval training and L-arginine supplementation on serum level of Irisin and body fat percentage in overweight and obese men: A Randomized Clinicai Trial
Sadegh Cheragh Birjandi 1, Marziyeh Saghebjoo *2, Mehdi Hedayati 3
1- PhD Student 1Department of Sport Sciences, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.
2- Associate Professor 1Department of Sport Sciences, Faculty of Sport Sciences, University of Birjand, Birjand, Iran. , m_saghebjoo@birjand.ac.ir
3- Associate Professor Cellular & Molecular Research Center, Research Institute for Endocrine Sciences & Metabolisms, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (164 Views)
Background and Objectives: Irisin, as a myokine, has been known in reducing obesity and converting white to brown adipose tissue. The purpose of this study was to investigate the effect of high-intensity interval training and L-arginine supplementation on serum level of Irisin and body fat percentage in overweight and obese men.
 
Methods: In this randomized clinical trial, 40 young healthy overweight and obese men (mean age, 24.5±6.5 years and body mass index, 29.4± 3.6kg/m2), were randomly assigned to 4 groups of high-intensity interval training, L-arginine supplementation, high-intensity interval training+L-arginine supplementation, and placebo. The training program consisted of 3 sessions/week high-speed interval running for 6 weeks. L-arginine supplement was consumed orally 6gr/day. Blood sampling and measurement of body fat percentage, was performed 24 hours before and 48 hours after training program and supplementation. Data were analyzed using ANCOVA and post-hoc Bonferroni tests (p<0.05).
 
Results: The serum level of irisin significantly increased following 6 weeks of high-intensity interval training and high-intensity interval training+L-arginine supplementation (pvalues= 0.017 and 0.019, respectively). While L-arginine consumption did not cause any significant changes in the level of irisin (p=0.19).  Body fat percentage had no significant changes following 6 weeks of high-intensity training and L-arginine consumption (p>0.05).
 
Conclusion: According to the findings of this study, 6 weeks of high-intensity interval training and high-intensity interval training accompanied by L-arginine supplementation can be an effective step in facilitating the activation of brown adipose tissue through increasing the serum level of irisin. Thus, high-intensity interval training can be used as a method in the treatment of obesity.
 

 
 
Keywords: High intensity interval training, Arginine, Irisin, Fat body, Randomized clinical trials.
Full-Text [PDF 546 kb]   (109 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی ورزشی
Received: 2016/06/10 | Accepted: 2016/08/4 | Published: 2017/11/20
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Cheragh Birjandi S, Saghebjoo M, Hedayati M. The effect of high-intensity Interval training and L-arginine supplementation on serum level of Irisin and body fat percentage in overweight and obese men: A Randomized Clinicai Trial. Qom Univ Med Sci J . 2017; 11 (9) :1-9
URL: http://journal.muq.ac.ir/article-1-910-en.html
Volume 11, Issue 9 (Novamber 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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