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:: Volume 11, Issue 10 (December 2017) ::
Qom Univ Med Sci J 2017, 11(10): 21-29 Back to browse issues page
Anti-Cancer Effect of Nano Zinc Oxide on Malignant HN5 Cell Line in In Vitro Culture
Elham Hoveizi 1, Tayebeh Mohammadi 2
1- 1Department of biology, Stem Cells & Transgenic Technology Research Center, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. , e.hoveizi@yahoo.com
2- Assistant Professor 1Department of biology, Stem Cells & Transgenic Technology Research Center, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Abstract:   (402 Views)
Background and Objectives: Head and neck cell carcinoma cell lines (HN-5) are considered as an appropriate preclinical model for new therapeutic purposes for this type of cancer. Unlike other cancers, Various primary and metastatic HN5 cell lines are available. The aim of this study was to investigate the anti-cancer effect of nano zinc oxide (ZnO) on viability of malignant HN5 cell line.
 
Methods: In this experimental study, HN5 cell line was cultured in DMEM medium (containing 10% FBS and penicillin/streptomycin) at 37°C. Then, the effect of different concentrations of ZnO on these cells, were assessed by MTT and DAPI staining. The results were evaluated with completely randomized block design ANOVA.
 
Results: In this study, some concentrations of ZnO were effective in cytotoxicity of HN5 cancer cells. Also, 300μg/ml was the concentration of the studied compound that reduced the highest percentage of cell viability.
 
Conclusion: The results of this study showed that ZnO has ability to induce cytotoxicity in HN5 cancer cell line in higher concentrations (about 300µg/ml), that these findings These findings provide a new perspective on the use nanoparticles in the cancer chemotherapy.
 
Keywords: Neoplasms, Zinc oxide, Cell survival, Head and neck neoplasms.
Full-Text [PDF 560 kb]   (131 Downloads)    
Type of Study: Original Article | Subject: سلولی و مولکولی
Received: 2016/06/28 | Accepted: 2016/10/10 | Published: 2017/12/17
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Hoveizi E, Mohammadi T. Anti-Cancer Effect of Nano Zinc Oxide on Malignant HN5 Cell Line in In Vitro Culture. Qom Univ Med Sci J . 2017; 11 (10) :21-29
URL: http://journal.muq.ac.ir/article-1-977-en.html
Volume 11, Issue 10 (December 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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