Volume 9, Issue 11 (January 2016)                   Qom Univ Med Sci J 2016, 9(11): 1-11 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Faghihi N, Mohammadi M T, Eidi A. The Effect of Atorvastatin on Oxidative Stress and Renal Function in Experimental Model of Diabetic Nephropathy. Qom Univ Med Sci J 2016; 9 (11) :1-11
URL: http://journal.muq.ac.ir/article-1-244-en.html
1- Science & Research Branch, Islamic Azad University
2- Baqiyatallah University of Medical Sciences , mohammadi.mohammadt@ yahoo.com
Abstract:   (8853 Views)

Background and Objectives: Atorvastatin has multiple effects independent of lipid lowering, such as anti-inflammatory and antioxidant. The present study was performed with the purpose of determining the effect of atorvastatin on renal function and oxidative stress response in experimental model of diabetic nephropathy.   Methods: In an experimental study, male Wistar rats were randomly divided into four groups (N=24): normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated rats received atorvastatin for 8 weeks (at dose of 40mg/kg/day). At the end of the experiment, blood samples were collected to measure glucose and creatinine levels. The concentration of malondialdehyde (MDA) and the activity of renal catalase were assessed.   Results: Chronic uncontrolled hyperglycemia (blood glucose>500mg/dl) significantly increased the blood creatinine in diabetic group (1.70±0.30mg/dl) compared to normal animals (0.40±0.07mg/dl), (p<0.05). Also, hyperglycemia caused a decrease in the activity of catalase enzyme (57%) along with an increase in the MDA concentration (0.15±0.02nmol/mg protein) compared to normal group (0.04±0.02nmol/mg protein). Atorvastatin significantly decreased the blood creatinine of diabetic animals (0.70±0.20mg/dl) compared to normal group (p<0.05). Finally, in the treated diabetic animals, renal activity of catalase enzyme increased (52%) and MDA concentration decreased (0.03±0.01nmol/mg protein).   Conclusion: The findings of this study indicated that atorvastatin is able to strengthen the renal antioxidant system during diabetic nephropathy. Therefore, it appears that atorvastatin prevents hyperglycemia-induced nephropathy through the inhibition of free radical production.

Full-Text [PDF 690 kb]   (3920 Downloads)    
Type of Study: Original Article | Subject: داخلی
Received: 2016/02/13 | Accepted: 2016/02/17 | Published: 2016/02/17

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Qom University of Medical Sciences Journal

Designed & Developed by : Yektaweb