Volume 19, Issue 1 (3-2025)
Qom Univ Med Sci J 2025, 19(1): 0-0 |
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Ethics code: IR.MUQ.REC.1402.108
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Miraj S, Arjmandnia M H, Atarod M, Yousefi M, Mohammadi A, Rahimi S, et al . The Relationship of Glycated Hemoglobin Levels With the Risk of Congenital Heart Defects in Infants of Diabetic Women. Qom Univ Med Sci J 2025; 19 (1) : 3186.1
URL: http://journal.muq.ac.ir/article-1-4082-en.html
URL: http://journal.muq.ac.ir/article-1-4082-en.html
Sepideh Miraj1 
, Mohammad Hosein Arjmandnia2 , Mohammadhossein Atarod3 , Maryam Yousefi *4 , Abotaleb Mohammadi2 , Shima Rahimi5 , Sajjad Rezvan6 , Elham Farasat2
, Mohammad Hosein Arjmandnia2 , Mohammadhossein Atarod3 , Maryam Yousefi *4 , Abotaleb Mohammadi2 , Shima Rahimi5 , Sajjad Rezvan6 , Elham Farasat2
1- Department of Obstetrics and Gynecology, School of Medicine, Nekouei-Hedayati-Forghani Hospital, Qom University of Medical Sciences, Qom, Iran.
2- Department of Pediatrics, School of Medicine, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran.
3- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
4- Department of Obstetrics and Gynecology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. ,mary.yousefi321@gmail.com
5- Department of Obstetrics and Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
6- Department of Radiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Department of Pediatrics, School of Medicine, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran.
3- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
4- Department of Obstetrics and Gynecology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. ,
5- Department of Obstetrics and Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
6- Department of Radiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Abstract: (788 Views)
Background and Objectives: Gestational diabetes is one of the most common complications of pregnancy with negative impacts on the health of both the mother and the fetus. Poor glycemic control in early pregnancy is associated with an increased risk of congenital anomalies, such as congenital heart defects (CHD) in newborns. This study aimed to investigate the impact of glycated hemoglobin (HbA1c) levels in pregnant women with diabetes on the occurrence of CHD in newborns.
Methods: This retrospective study was conducted on 84 pregnant women with diabetes who visited Hazrat-e Masoumeh Hospital in Qom, Iran, during 2021-2022. The HbA1c level was recorded as an indicator of glycemic control in mothers, and fetal cardiac abnormalities were assessed through echocardiography. The data were analyzed in SPSS software, version 26.
Results: Out of 84 women, 42.5% had an HbA1c level <8.5 (controlled diabetes), while 57.1% had an HbA1c level >8.5 (uncontrolled diabetes). In the group with HbA1c≥8.5, the five-minute Apgar score was significantly lower (P=0.001). Additionally, fetal cardiac abnormalities were significantly more prevalent in this group (15.5% vs 2.4%, P=0.011). However, in terms of specific types of CHD, no significant difference was observed between the two groups (P>0.05).
Conclusion: Poor glycemic control (HbA1c≥8.5) in pregnant women with pre-existing diabetes is significantly associated with an increased risk of CHD and a lower five-minute Apgar score. These findings underscore the importance of precise glycemic control during the first trimester for preventing fetal complications. Enhancing prevention programs and healthcare measures, including education, early screening, and the use of advanced technologies, can help reduce the risks associated with diabetes during pregnancy.
Methods: This retrospective study was conducted on 84 pregnant women with diabetes who visited Hazrat-e Masoumeh Hospital in Qom, Iran, during 2021-2022. The HbA1c level was recorded as an indicator of glycemic control in mothers, and fetal cardiac abnormalities were assessed through echocardiography. The data were analyzed in SPSS software, version 26.
Results: Out of 84 women, 42.5% had an HbA1c level <8.5 (controlled diabetes), while 57.1% had an HbA1c level >8.5 (uncontrolled diabetes). In the group with HbA1c≥8.5, the five-minute Apgar score was significantly lower (P=0.001). Additionally, fetal cardiac abnormalities were significantly more prevalent in this group (15.5% vs 2.4%, P=0.011). However, in terms of specific types of CHD, no significant difference was observed between the two groups (P>0.05).
Conclusion: Poor glycemic control (HbA1c≥8.5) in pregnant women with pre-existing diabetes is significantly associated with an increased risk of CHD and a lower five-minute Apgar score. These findings underscore the importance of precise glycemic control during the first trimester for preventing fetal complications. Enhancing prevention programs and healthcare measures, including education, early screening, and the use of advanced technologies, can help reduce the risks associated with diabetes during pregnancy.
Article number: 3186.1
Type of Study: Original Article |
Subject:
مدیریت بهداشتی
Received: 2025/02/18 | Accepted: 2025/04/29 | Published: 2025/03/30
Received: 2025/02/18 | Accepted: 2025/04/29 | Published: 2025/03/30
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