Volume 8, Issue 4 (9-2014)                   Qom Univ Med Sci J 2014, 8(4): 1-5 | Back to browse issues page

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Sasaninejad Z, Eidi M, Ghahramani R, Ahmarinejad Z, Rezaei Galeshpol A, Rasoulian F, et al . Anxiolytic Effect of L-carnitine in Adult Male Rats. Qom Univ Med Sci J 2014; 8 (4) :1-5
URL: http://journal.muq.ac.ir/article-1-183-en.html
1- Islamic Azad University, Tehran Medical Sciences Branch
2- Islamic Azad University, Varamin-Pishva Branch , maryameidi@gmail.com
3- Islamic Azad University, Varamin-Pishva Branch
Abstract:   (5075 Views)

Background and Objectives: The beneficial effect of L-carnitine for treatment of neurological diseases has been investigated in various studies. The aim of the present study was to investigate the effect of L-carnitine supplement on anxiety behavior in adult male rats by elevated plus maze.   Methods: In this experimental study, the studied groups were divided into normal, saline, and experimental groups. L-carnitine was administered intraperitoneally at doses of 0.5, 1, 2, and 4 mg/kg were, and saline control group received saline as vehicle. The data were analyzed using one-way ANOVA and Dunnett’s test. The significance level was considered as p<0.05.   Results: In this study, the anxiolytic response of the drug was evaluated by elevated plus maze 30 minutes after treatment. L-carnitine treatment increase time spent in open arms, number of entries into open and dark arms or locomotor activity, %OAE, while decreased %OAT (p<0.01). Conclusion: The results of this study indicated that L-carnitine has anxiolytic effect on male rats

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Type of Study: Original Article |
Received: 2016/02/13 | Accepted: 2016/02/23 | Published: 2016/02/23

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