Volume 14, Issue 10 (December 2020)                   Qom Univ Med Sci J 2020, 14(10): 25-33 | Back to browse issues page

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Seifi Nahavandi B, Yaghmaei P, Ahmadian S, Ebrahim-Habibi A, Ghobeh M. Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats. Qom Univ Med Sci J 2020; 14 (10) :25-33
URL: http://journal.muq.ac.ir/article-1-2934-en.html
Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats
Bahareh Seifi Nahavandi1 , Parichehreh Yaghmaei * 2, Shahin Ahmadian3 , Azadeh Ebrahim-Habibi4 , Maryam Ghobeh1
1- Department of Biology, Science and Research Branch, Islamic Azad University
2- Department of Biology, Science and Research Branch, Islamic Azad University , yaghmaei_p@srbiau.ac.ir
3- Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran
4- Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences
Abstract:   (2302 Views)
Background and Objectives: Alzheimer's disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of terpinolene and physical activity on memory and learning in a model of Alzheimer's rats.
 
Methods: Bilateral injection of AB1-42 was administered to the hippocampus of the male rats to create the model of Alzheimer's disease. The assigned groups included control (-), sham, exercise, control (+), Alzheimer's+distilled water, Alzheimer's+exercise, Alzheimer's+terpinolene (treatment), Alzheimer's+terpinolene (prevention), and Alzheimer's+terpinolene+exercise. Superoxide dismutase (SOD), Malondialdehyde (MDA) level, shuttle box behavioral test, as well as neurogenesis and amyloid plaques were assessed in this study. The data were statistically analyzed using one-way ANOVA.
 
Results: The SOD activity and neurogenesis levels decreased significantly in the control (+) group, compared to control groups of the behavioral test. However, the MDA level and plaque increased significantly (P<0.05). Terpinolene intake and exercise caused a significant increase in neurogenesis, a significant decrease in plaques, and significant changes in biochemical and behavioral parameters (P<0.05).
 
Conclusion: Based on the results of this study and previous reports on the antioxidant and anti-inflammatory effects of terpinolene and exercise, it seems that this combination along with exercise can improve memory complications and disorders. 
 
Keywords: Alzheimer’s disease, Amyloid beta-peptides, Exercise, Rats, Terpinolene.
Full-Text [PDF 1033 kb]   (759 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2020/09/26 | Accepted: 2021/01/9 | Published: 2020/12/30
References
1. Ittner LM, Gotz J. Amyloid-β and tau-a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 2011;12(2):65-72. DOI: 10.1038/nrn2967 [DOI:10.1038/nrn2967]
2. Fathi F, Hatami H, Ali Hemmati AR, Banan Khojasteh SM. Effects of sesame oil on improving spatial memory in alzheimers disease. J Babol Univ Med Sci 2014;16(2):34-41. DOI: 10.18869/acadpub.jbums.16.2.34
3. Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M. Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol Sci 2017;38(7):592-607. DOI: 10.1016/j.tips.2017.04.005 [DOI:10.1016/j.tips.2017.04.005]
4. Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, et al. Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients. Stem Cell Res 2018;27:121-30. DOI: 10.1016/j.scr.2018.01.019 [DOI:10.1016/j.scr.2018.01.019]
5. Soydinç S, Çelik A, Demiryürek S, Davutoğlu V, Tarakçıoğlu M, Aksoy M. The relationship between oxidative stress, nitric oxide, and coronary artery disease. Eur J Gen Med 2007;4(2):62-6. Link [DOI:10.29333/ejgm/82487]
6. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996;48(6):835-50. DOI: 10.1016/s0090-4295(96)00313-5 [DOI:10.1016/S0090-4295(96)00313-5]
7. Um HS, Kang EB, Koo JH, Kim HT, Jin L, Kim EJ, et al. Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease. Neurosci Res 2011;69(2):161-73. DOI: 10.1016/j.neures.2010.10.004 [DOI:10.1016/j.neures.2010.10.004]
8. Case AJ. On the origin of superoxide dismutase: an evolutionary perspective of superoxide-mediated redox signaling. Antioxidants 2017;6(4):82. DOI: 10.3390/antiox6040082 [DOI:10.3390/antiox6040082]
9. He L, He T, Farrar S, Ji L, Liu T, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 2017;44(2):532-53. DOI: 10.1159/000485089 [DOI:10.1159/000485089]
10. Janyou A, Wicha P, Jittiwat J, Suksamrarn A, Tocharus C, Tocharus J. Dihydrocapsaicin attenuates blood brain barrier and cerebral damage in focal cerebral ischemia/reperfusion via oxidative stress and inflammatory. Sci Rep 2017;7(1):10556. DOI: 10.1038/s41598-017-11181-5 [DOI:10.1038/s41598-017-11181-5]
11. Dinda B, Chowdhury DR, Mohanta BC. Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3. Chem Pharm Bull (Tokyo) 2009;57(8):765-96. DOI: 10.1248/cpb.57.765 [DOI:10.1248/cpb.57.765]
12. Brauss MS, Linforth RS, Cayeux I, Harvey B, Taylor AJ. Altering the fat content affects flavor release in a model yogurt system. J Agric Food Chem 1999;47(5):2055-9. DOI: 10.1021/jf9810719 [DOI:10.1021/jf9810719]
13. Falk AA, Hagberg MT, Lof AE, Wigaeus-Hjelm EM, Zhiping W. Uptake, distribution and elimination of alphapinene in man after exposure by inhalation. Scand J Work Environ Health 1990;16(5):372-8. DOI: 10.5271/sjweh.1771 [DOI:10.5271/sjweh.1771]
14. Smith AD, Zigmond MJ. Can the brain be protected through exercise? Lessons from an animal model of Parkinsonism. Exp Neurol 2003;184(1):31-9. DOI: 10.1016/j.expneurol.2003.08.017 [DOI:10.1016/j.expneurol.2003.08.017]
15. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011;108(7):3017-22. DOI: 10.1073/pnas.1015950108 [DOI:10.1073/pnas.1015950108]
16. Dall'Igna OP, Fett P, Gomes MW, Souza DO, Cunha RA, Lara DR. Caffeine and adenosine A(2a) receptor antagonists prevent β-amyloid (25-35)-induced cognitive deficits in mice. Exp Neurol 2007;203(1):241-5. DOI: 10.1016/j.expneurol.2006.08.008 [DOI:10.1016/j.expneurol.2006.08.008]
17. Aydın E, Türkez H, Sait Keleş M. The effect of carvacrol on healthy neurons and N2a cancer cells: some biochemical, anticancerogenicity and genotoxicity studies. Cytotechnology 2013;66(1):149-57. DOI: 10.1007/s10616-013-9547-5 [DOI:10.1007/s10616-013-9547-5]
18. Eslimi Esfehani D, Oryan SH, Khosravi M, Valizadegan F. effect of fennel extract on the improvement of memory disorders in beta amyloid alzheimer model of male wistar rats. Sci J Ilam Univ Med Sci 2019,27(1):1-12. DOI: 10.29252/sjimu.27.1.1 [DOI:10.29252/sjimu.27.1.1]
19. Alaei H, Moloudi R, Sarkaki AR. Effects of treadmill running on mid-term memory and swim speed in the rat with Morris water maze test. J Bodywork Movement Ther 2008;12(1):72-5. DOI: 10.1016/j.jbmt.2007.05.004 [DOI:10.1016/j.jbmt.2007.05.004]
20. Zarrindast M, Madadi F, Ahmadi S. Repeated administrations of dopamine receptor agents affect lithium-induced state-dependent learning in mice. J Psychopharmacol 2009;23(6):645-51. DOI: 10.1177/0269881108093926 [DOI:10.1177/0269881108093926]
21. Liu J, Wang A, Li L, Huang Y, Xue P, Hao A. Oxidative stress mediates hippocampal neurondeath in rats after lithium-pilocarpineinduced status epilepticus. Seizure 2010;19(3):165-72. DOI: 10.1016/j.seizure.2010.01.010 [DOI:10.1016/j.seizure.2010.01.010]
22. Batista PA, Werner MF, Oliveira EC, Burgos L, Pereira P, Brum LF, et al. The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. J Pain 2010;11(11):1222-9. DOI: 10.1016/j.jpain.2010.02.022 [DOI:10.1016/j.jpain.2010.02.022]
23. Wu Q, Yu L, Qiu J, Shen B, Wang D, Soromou LW, et al. Linalool attenuates lung inflammation induced by Pasteurella multocida via activating Nrf-2 signaling pathway. Int Immunopharmacol 2014;21(2):456-63. DOI: 10.1016/j.intimp.2014.05.030 [DOI:10.1016/j.intimp.2014.05.030]
24. Li J, Zhang X, Huang H. Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Int Immunopharmacol 2014;23(2):523-9. DOI: 10.1016/j.intimp.2014.10.001 [DOI:10.1016/j.intimp.2014.10.001]
25. Beier RC, Byrd JA, Kubena LF, Hume ME, McReynolds JL, Anderson RC, et al. Evaluation of linalool, a natural antimicrobial and insecticidal essential oil from basil: effects on poultry. Poult Sci 2014;93(2):267-72. DOI: 10.3382/ps.2013-03254 [DOI:10.3382/ps.2013-03254]
26. Saadati H, Babri S, Ahmadiasl N, Mashhadi M. Effects of exercise on memory concolidation and retrieval of passive avoidance learning in young male rats. Asian J Sports Med 2010;1(3):137-42. DOI: 10.5812/asjsm.34858 [DOI:10.5812/asjsm.34858]
27. Liu HI, Zhao G, Zhang H, Shi LD. Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/ PS1 transgenic mice. Behav Brain Res 2013;256:261-72. DOI: 10.1016/j.bbr.2013.08.008 [DOI:10.1016/j.bbr.2013.08.008]
28. Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am J Pathol 1992;140(3):621-8. Link
29. Massaad CA, Washington TM, Pautler RG, Klann E. Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2009;106(32):13576-81. DOI: 10.1073/pnas.0902714106 [DOI:10.1073/pnas.0902714106]
30. Costa DA, de Oliveira GA, Lima TC, dos Santos PS, de Sousa DP, de Freitas RM. Anticonvulsant and antioxidant effects of cyano-carvone and its action on acetylcholinesterase activity in mice hippocampus. Cell Mol Neurobiol 2012;32(4):633-40. DOI: 10.1007/s10571-012-9812-8 [DOI:10.1007/s10571-012-9812-8]
31. Trabace L, Kendrick KM, Castrignano S, Colaianna M, De Giorgi A, Schiavone S, et al. Soluble amyloid beta1-42 reduces dopamine levels in rat prefrontal cortex: relationship to nitric oxide. Neuroscience 2007;147(3):652-63. DOI: 10.1016/j.neuroscience.2007.04.056 [DOI:10.1016/j.neuroscience.2007.04.056]
32. Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW. A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A 1975;72(5):1858-62. DOI: 10.1073/pnas.72.5.1858 [DOI:10.1073/pnas.72.5.1858]
33. Celik S, Ozkaya A. Effects of intraperitoneally administered lipoic acid, vitamin E, and linalool on the level of total lipid and fatty acids in guinea pig brain with oxidative stress induced by H2O2. J Biochem Mol Biol 2002;35(6):547-52. DOI: 10.5483/bmbrep.2002.35.6.547 [DOI:10.5483/BMBRep.2002.35.6.547]
34. Macedo EM, Santos WC, Sousa BP Neto, Lopes EM, Piauilino CA, Cunha FV, et al. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. Braz J Med Biol Res 2016;49(7):e5103. DOI: 10.1590/1414-431X20165103 [DOI:10.1590/1414-431x20165103]
35. Hong JT. NF-kB as a mediator of brain inflammation in AD. CNS Neurol Disord Drug Targets 2017;16(1):18715366. Link
36. Habtemariam S. Protective effects of caffeic acid and the Alzheimer's brain: an update. Mini Rev Med Chem 2017;17(8):667-74. DOI: 10.2174/1389557516666161130100947 [DOI:10.2174/1389557516666161130100947]
37. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci 2005;25(17):4217-21. DOI: 10.1523/JNEUROSCI.0496-05.2005 [DOI:10.1523/JNEUROSCI.0496-05.2005]
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