Volume 11, Issue 5 (July 2017)                   Qom Univ Med Sci J 2017, 11(5): 9-15 | Back to browse issues page

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Sari S, Sari G. An Investigation of the Relationship between PPP1R3 Gene Polymorphism and Type 2 Diabetes. Qom Univ Med Sci J 2017; 11 (5) :9-15
URL: http://journal.muq.ac.ir/article-1-881-en.html
1- Department of Cellular & Molecular Sciences, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- Department of Chemical Engineering, Faculty of Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (5089 Views)

Background and Objectives: PPP1R3 is one of the genes confirmed to be associated with type 2 diabetes. This gene is located on the long arm of chromosome 7 and encodes protein phosphatase 1 (PP1), which has serine/threonine phosphatase activity. There is a polymorphic region in the 3'UTR region of this gene, which creates ARE1 and ARE2 alleles. The aim of this study was to determine the relationship between PPP1R3 gene polymorphism and type 2 diabetes.

Methods: In this case-control study, 100 patients with type 2 diabetes and 100 healthy individuals, were randomly selected from the study population. PPP1R3 gene polymorphism was analyzed using PCR-RFLP method. Comparison of variables between healthy and patient groups, was performed by t-test, allele frequency by counting, and calculation of their ratio by chi-square test, and the population was confirmed to be in Hardy-Weinberg equilibrium. Distribution of genotypes and alleles was compared between healthy and patient groups.

Results: In this study, there was no significant difference between the frequency of genotypes and frequency of alleles in subjects with type 2 diabetes and healthy control subjects.

Conclusion: The findings of this study indicated that polymorphisms in the 3'UTR region of PPP1R3 gene is not associated with type 2 diabetes.

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Type of Study: Original Article | Subject: ژنتیک
Received: 2016/05/29 | Accepted: 2016/06/23 | Published: 2017/07/19

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