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:: دوره 14، شماره 4 - ( تیر 1399 ) ::
جلد 14 شماره 4 صفحات 11-21 برگشت به فهرست نسخه ها
تأثیر تمرین هوازی و عصاره رزماری بر فاکتورهای التهابی در مخچه رت‌های نر مسن
رحمان سوری1 ، ‌ حسن وحدت1 ، فاطمه شب خیز1 ، شیما آب آب زاده 2، محسن اسلامی فارسانی3
1- گروه تربیت‌بدنی و علوم تمرینی، دانشکده تربیت‌بدنی، دانشگاه تهران
2- مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی قم ، shimaababzadeh@gmail.com
3- گروه علوم تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی قم
چکیده:   (1967 مشاهده)
زمینه و هدف: تغییر در بیان سایتوکاین‌های پیش‌التهابی نقش مهمی در تسریع روند پیری مغز دارد. مصرف برخی گیاهان سنتی با خاصیت آنتی‌اکسیدانی و ضدالتهابی (همانند رزماری) و انجام تمرین­های هوازی به‌صورت منظم ممکن است ازجمله عوامل مؤثر در کنترل پیری زودرس ­باشند. این مطالعه با هدف بررسی تأثیر تمرین هوازی و مصرف عصاره رزماری بر میزان TNF-α و IL-6 در بافت مخچه موش­های صحرایی نر پیر طراحی شده است.
روش بررسی: تعداد 40 سر رت نر نژاد ویستار ۱۸ ماهه با میانگین وزنی 350 تا 450 گرم انتخاب و به‌طور تصادفی به پنج گروه کنترل، شم (تردمیل خاموش و گاواژ آب مقطر)، تمرین (۱۲ هفته، ۵ روز هفته)، مکمل یا عصاره (۱۲ هفته روزانه ۱۰۰ میلی‌گرم به‌ازای هر کیلوگرم عصاره رزماری گاواژ شد) و تمرین-مکمل (عصاره) تقسیم شدند. یک روز بعد ‌از آخرین جلسه تمرین، بافت مخچه با رعایت تمام اصول اخلاقی به‌سرعت از جمجمه خارج و پس از هموژنیزاسیون، میزان TNF-α و IL-6 با تکنیک الایزا ارزیابی شد. داده­ها با استفاده از آزمون واریانس یک‌طرفه و آزمون تعقیبی توکی تجزیه‌وتحلیل شدند.
یافته‌ها: طبق نتایج حاصل از این مطالعه، افزایش معنی‌داری در میزان IL-6 در گروه تمرین و گروه مکمل نسبت به گروه کنترل و شم (05/0P<) و همچنین افزایش معنی‌داری در گروه تمرین-مکمل هم‌زمان نسبت به کنترل (01/0P<) و شم مشاهده شد (001/0P<). از طرفی میزان پروتئین TNF-α در گروه‌های تیماری نسبت به شم و کنترل کاهش نشان داد که معنی‌دار نبود.
نتیجه‌گیری: بر اساس یافته‌های این پژوهش ‌به ‌نظر می‌رسد تمرین هوازی به همراه مصرف مکمل عصاره رزماری بر میزان تولید و تعادل بین سایتوکاین‌های پیش‌التهابی در ناحیه مخچه رت‌های پیر می‌تواند مؤثر باشد.
واژه‌های کلیدی: پیری، تمرینات هوازی، عصاره رزماری، مخچه، TNF-α، IL6
متن کامل [PDF 1085 kb]   (279 دریافت) |   |   متن کامل (HTML)  (187 مشاهده)  
نوع مطالعه: مقاله پژوهشي | موضوع مقاله: علوم پایه
دریافت: 1398/3/25 | پذیرش: 1399/4/3 | انتشار: 1399/4/10
فهرست منابع
1. 1. Mirzaie M, Darabi S. Population aging in Iran and rising health care costs. Iran J Ageing 2017;12(2):156-69. Link [DOI:10.21859/sija-1202156]
2. Joseph JA. The putative role of free radicals in the loss of neuronal functioning in senescence. Integr Physiol Behav Sci 1992;27(3):216-27. PMID: 1419868 [DOI:10.1007/BF02690894]
3. da Silva SG, Simões PSR, Mortara RA, Scorza FA, Cavalheiro EA, da Graça Naffah-Mazzacoratti M, et al. Exercise-induced hippocampal anti-inflammatory response in aged rats. 2013;10(1):827. link [DOI:10.1186/1742-2094-10-61]
4. Franzke B, Schober-Halper B, Hofmann M, Oesen S, Tosevska A, Strasser EM, et al. Fat soluble vitamins in institutionalized elderly and the effect of exercise, nutrition and cognitive training on their status-the vienna active aging study (VAAS): a randomized controlled trial. Nutrients 2019;11(6):1333. Link [DOI:10.3390/nu11061333]
5. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 2018;9(24):17181-98. PMID: 29682215 [DOI:10.18632/oncotarget.24729]
6. Hou CW, Chen IC, Shu FR, Feng CH, Hung CT. Protective effect of supplementation with Lycium ruthenicum Murray extract from exhaustive exercise-induced cardiac injury in rats. Chin Med J 2019;132(8):1005-6. PMID: 30958451 [DOI:10.1097/CM9.0000000000000185]
7. Chapman NH, Fisk I, Craigon J, Towey C, Grant I, Brewer J. Exploring the effects of tomato extract supplementation on cognitive function during exercise and at rest. J Nutr Health Sci 2019;6(2):203. Link
8. Rasoolijazi H, Mehdizadeh M, Soleimani M, Nikbakhte F, Farsani ME, Ababzadeh S. The effect of rosemary extract on spatial memory, learning and antioxidant enzymes activities in the hippocampus of middle-aged rats. Med J Islam Repub Iran 2015;29:187. PMID: 26034740
9. Ababzadeh S, Iravani A, Fallahian F, Aghamiri SM. Histological and morphological studies of cardiac cells in response to aerobic exercise and rosemary extract in rat model of aging. J Morphol Sci 2018;35(04):266-71. Link [DOI:10.1055/s-0038-1676778]
10. Romano CS, Abadi K, Repetto V, Vojnov AA, Moreno S. Synergistic antioxidant and antibacterial activity of rosemary plus butylated derivatives. Food Chem 2009;115(2):456-61. Link [DOI:10.1016/j.foodchem.2008.12.029]
11. Moore J, Yousef M, Tsiani E. Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols. Nutrients 2016;8(11):E731. PMID: 27869665 [DOI:10.3390/nu8110731]
12. Vlavcheski F, Baron D, Vlachogiannis IA, MacPherson RE, Tsiani E. Carnosol increases skeletal muscle cell glucose uptake via AMPK-dependent GLUT4 glucose transporter translocation. Int J Mol Sci 2018;19(5):E1321. PMID: 29710819 [DOI:10.3390/ijms19051321]
13. Dimauro I, Paronetto MP, Caporossi D. Exercise, redox homeostasis and the epigenetic landscape. Redox Biol 2020;35:101477. PMID: 32127290 [DOI:10.1016/j.redox.2020.101477]
14. Camus G, Deby-Dupont G, Deby C, Juchmes-Ferir A, Pincemail J, Lamy M. Inflammatory response to strenuous muscular exercise in man. Mediators Inflamm 1993;2(5):335-42. PMID: 18475542 [DOI:10.1155/S0962935193000468]
15. Finaud J, Scislowski V, Lac G, Durand D, Vidalin H, Robert A, et al. Antioxidant status and oxidative stress in professional rugby players: evolution throughout a season. Int J Sports Med 2006;27(2):87-93. PMID: 16475052 [DOI:10.1055/s-2005-837489]
16. Sen C, Packer L, Hänninen O. Handbook of oxidants and antioxidants in exercise. New York: Elsevier; 2000. Link
17. Fatouros IG, Kouretas D. Exercise, oxidative stress, and inflammation. Exer Physiol 2010;75:245. Link
18. Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008;44(2):153-9. PMID: 18191751 [DOI:10.1016/j.freeradbiomed.2007.01.029]
19. Cotman CW, Berchtold NC. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement 2007;3(2 Suppl):S30-7. PMID: 19595972 [DOI:10.1016/j.jalz.2007.01.013]
20. Suvarna KS, Layton C, Bancroft JD. Bancroft's theory and practice of histological techniques E-Book. New York: Elsevier Health Sciences; 2018. Link
21. Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Morán M, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res 2015;18(1):57-89. PMID: 25431878 [DOI:10.1089/rej.2014.1623]
22. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007;43(4):477-503. PMID: 17640558 [DOI:10.1016/j.freeradbiomed.2007.03.034]
23. Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 2007;17(6):1525-31. PMID: 17487414 [DOI:10.3892/or.17.6.1525]
24. Munné-Bosch S, Alegre L. Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary. Plant Physiol 2001;125(2):1094-102. PMID: 11161064 [DOI:10.1104/pp.125.2.1094]
25. Arranz E, Jaime L, García‐Risco MR, Fornari T, Reglero G, Santoyo S. Anti‐inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol. Int J Food Sci Technol 2015;50(3):674-81. Link [DOI:10.1111/ijfs.12656]
26. Namita P, Mukesh R, Vijay KJ. Camellia sinensis (green tea): a review. Global J Pharmacol 2012;6(2):52-9. Link
27. Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hörnig C, et al. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol 2008;76(1):91-7. PMID: 18508031 [DOI:10.1016/j.bcp.2008.04.013]
28. Azad N, Rasoolijazi H, Joghataie MT, Soleimani S. Neuroprotective effects of carnosic acid in an experimental model of Alzheimer's disease in rats. Cell J 2011;13(1):39-44. PMID: 23671826
29. Nybo L, Nielsen B, Pedersen BK, Møller K, Secher NH. Interleukin‐6 release from the human brain during prolonged exercise. J Physiol 2002;542(Pt 3):991-5. PMID: 12154196 [DOI:10.1113/jphysiol.2002.022285]
30. Bauer S, Kerr BJ, Patterson PH. The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 2007;8(3):221-32. PMID: 17311007 [DOI:10.1038/nrn2054]
31. Deverman BE, Patterson PH. Cytokines and CNS development. Neuron 2009;64(1):61-78. PMID: 19840550 [DOI:10.1016/j.neuron.2009.09.002]
32. Van Wagoner NJ, Benveniste EN. Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol 1999;100(1-2):124-39. PMID: 10695723 [DOI:10.1016/S0165-5728(99)00187-3]
33. Moss AD. The impact of endurance exercise intensity on local and systemic hormonal and cytokine responses in the recreationally active young and old. Manchester: Manchester Metropolitan University; 2015. Link
34. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 2005;98(4):1154-62. PMID: 15772055 [DOI:10.1152/japplphysiol.00164.2004]
35. Chennaoui M, Drogou C, Gomez-Merino D. Effects of physical training on IL-1β, IL-6 and IL-1ra concentrations in various brain areas of the rat. European cytokine network. 2008;19(1):8-14. link
36. Chennaoui M, Drogou C, Gomez-Merino D. Effects of physical training on IL-1β, IL-6 and IL-1ra concentrations in various brain areas of the rat. Eur Cytokine Netw 2008;19(1):8-14. PMID: 18299269
37. Gustafson B, Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006;281(14):9507-16. PMID: 16464856 [DOI:10.1074/jbc.M512077200]
38. Leite MR, Cechella JL, Mantovani AC, Duarte MM, Nogueira CW, Zeni G. Swimming exercise and diphenyl diselenide-supplemented diet affect the serum levels of pro-and anti-inflammatory cytokines differently depending on the age of rats. Cytokine 2015;71(1):119-23. PMID: 25307207 [DOI:10.1016/j.cyto.2014.09.006]
39. Jahangiri RJ, Farzanegi P, Habibian MH. The effect of aerobic training and arbotin on cardiac nitric oxide, tumor necrosis factor alpha, and vascular endothelial growth factor in male diabetic rats. Qom Univ Med Sci J 2017;11(5):53-62. Link
40. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22(9):791-7. PMID: 11350112
41. Heled Y, Dror Y, Moran DS, Rosenzweig T, Sampson SR, Epstein Y, et al. Physical exercise increases the expression of TNFα and GLUT 1 in muscle tissue of diabetes prone Psammomys obesus. Life Sci 2005; 77(23):2977-85. PMID: 16043194 [DOI:10.1016/j.lfs.2005.05.033]
42. Mirzaie M, Darabi S. Population aging in Iran and rising health care costs. Iran J Ageing 2017;12(2):156-69. Link [DOI:10.21859/sija-1202156]
43. Joseph JA. The putative role of free radicals in the loss of neuronal functioning in senescence. Integr Physiol Behav Sci 1992;27(3):216-27. PMID: 1419868 [DOI:10.1007/BF02690894]
44. da Silva SG, Simões PSR, Mortara RA, Scorza FA, Cavalheiro EA, da Graça Naffah-Mazzacoratti M, et al. Exercise-induced hippocampal anti-inflammatory response in aged rats. 2013;10(1):827. link [DOI:10.1186/1742-2094-10-61]
45. Franzke B, Schober-Halper B, Hofmann M, Oesen S, Tosevska A, Strasser EM, et al. Fat soluble vitamins in institutionalized elderly and the effect of exercise, nutrition and cognitive training on their status-the vienna active aging study (VAAS): a randomized controlled trial. Nutrients 2019;11(6):1333. Link [DOI:10.3390/nu11061333]
46. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 2018;9(24):17181-98. PMID: 29682215 [DOI:10.18632/oncotarget.24729]
47. Hou CW, Chen IC, Shu FR, Feng CH, Hung CT. Protective effect of supplementation with Lycium ruthenicum Murray extract from exhaustive exercise-induced cardiac injury in rats. Chin Med J 2019;132(8):1005-6. PMID: 30958451 [DOI:10.1097/CM9.0000000000000185]
48. Chapman NH, Fisk I, Craigon J, Towey C, Grant I, Brewer J. Exploring the effects of tomato extract supplementation on cognitive function during exercise and at rest. J Nutr Health Sci 2019;6(2):203. Link
49. Rasoolijazi H, Mehdizadeh M, Soleimani M, Nikbakhte F, Farsani ME, Ababzadeh S. The effect of rosemary extract on spatial memory, learning and antioxidant enzymes activities in the hippocampus of middle-aged rats. Med J Islam Repub Iran 2015;29:187. PMID: 26034740
50. Ababzadeh S, Iravani A, Fallahian F, Aghamiri SM. Histological and morphological studies of cardiac cells in response to aerobic exercise and rosemary extract in rat model of aging. J Morphol Sci 2018;35(04):266-71. Link [DOI:10.1055/s-0038-1676778]
51. Romano CS, Abadi K, Repetto V, Vojnov AA, Moreno S. Synergistic antioxidant and antibacterial activity of rosemary plus butylated derivatives. Food Chem 2009;115(2):456-61. Link [DOI:10.1016/j.foodchem.2008.12.029]
52. Moore J, Yousef M, Tsiani E. Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols. Nutrients 2016;8(11):E731. PMID: 27869665 [DOI:10.3390/nu8110731]
53. Vlavcheski F, Baron D, Vlachogiannis IA, MacPherson RE, Tsiani E. Carnosol increases skeletal muscle cell glucose uptake via AMPK-dependent GLUT4 glucose transporter translocation. Int J Mol Sci 2018;19(5):E1321. PMID: 29710819 [DOI:10.3390/ijms19051321]
54. Dimauro I, Paronetto MP, Caporossi D. Exercise, redox homeostasis and the epigenetic landscape. Redox Biol 2020;35:101477. PMID: 32127290 [DOI:10.1016/j.redox.2020.101477]
55. Camus G, Deby-Dupont G, Deby C, Juchmes-Ferir A, Pincemail J, Lamy M. Inflammatory response to strenuous muscular exercise in man. Mediators Inflamm 1993;2(5):335-42. PMID: 18475542 [DOI:10.1155/S0962935193000468]
56. Finaud J, Scislowski V, Lac G, Durand D, Vidalin H, Robert A, et al. Antioxidant status and oxidative stress in professional rugby players: evolution throughout a season. Int J Sports Med 2006;27(2):87-93. PMID: 16475052 [DOI:10.1055/s-2005-837489]
57. Sen C, Packer L, Hänninen O. Handbook of oxidants and antioxidants in exercise. New York: Elsevier; 2000. Link
58. Fatouros IG, Kouretas D. Exercise, oxidative stress, and inflammation. Exer Physiol 2010;75:245. Link
59. Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008;44(2):153-9. PMID: 18191751 [DOI:10.1016/j.freeradbiomed.2007.01.029]
60. Cotman CW, Berchtold NC. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement 2007;3(2 Suppl):S30-7. PMID: 19595972 [DOI:10.1016/j.jalz.2007.01.013]
61. Suvarna KS, Layton C, Bancroft JD. Bancroft's theory and practice of histological techniques E-Book. New York: Elsevier Health Sciences; 2018. Link
62. Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Morán M, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res 2015;18(1):57-89. PMID: 25431878 [DOI:10.1089/rej.2014.1623]
63. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007;43(4):477-503. PMID: 17640558 [DOI:10.1016/j.freeradbiomed.2007.03.034]
64. Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 2007;17(6):1525-31. PMID: 17487414 [DOI:10.3892/or.17.6.1525]
65. Munné-Bosch S, Alegre L. Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary. Plant Physiol 2001;125(2):1094-102. PMID: 11161064 [DOI:10.1104/pp.125.2.1094]
66. Arranz E, Jaime L, García‐Risco MR, Fornari T, Reglero G, Santoyo S. Anti‐inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol. Int J Food Sci Technol 2015;50(3):674-81. Link [DOI:10.1111/ijfs.12656]
67. Namita P, Mukesh R, Vijay KJ. Camellia sinensis (green tea): a review. Global J Pharmacol 2012;6(2):52-9. Link
68. Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hörnig C, et al. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol 2008;76(1):91-7. PMID: 18508031 [DOI:10.1016/j.bcp.2008.04.013]
69. Azad N, Rasoolijazi H, Joghataie MT, Soleimani S. Neuroprotective effects of carnosic acid in an experimental model of Alzheimer's disease in rats. Cell J 2011;13(1):39-44. PMID: 23671826
70. Nybo L, Nielsen B, Pedersen BK, Møller K, Secher NH. Interleukin‐6 release from the human brain during prolonged exercise. J Physiol 2002;542(Pt 3):991-5. PMID: 12154196 [DOI:10.1113/jphysiol.2002.022285]
71. Bauer S, Kerr BJ, Patterson PH. The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 2007;8(3):221-32. PMID: 17311007 [DOI:10.1038/nrn2054]
72. Deverman BE, Patterson PH. Cytokines and CNS development. Neuron 2009;64(1):61-78. PMID: 19840550 [DOI:10.1016/j.neuron.2009.09.002]
73. Van Wagoner NJ, Benveniste EN. Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol 1999;100(1-2):124-39. PMID: 10695723 [DOI:10.1016/S0165-5728(99)00187-3]
74. Moss AD. The impact of endurance exercise intensity on local and systemic hormonal and cytokine responses in the recreationally active young and old. Manchester: Manchester Metropolitan University; 2015. Link
75. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 2005;98(4):1154-62. PMID: 15772055 [DOI:10.1152/japplphysiol.00164.2004]
76. Chennaoui M, Drogou C, Gomez-Merino D. Effects of physical training on IL-1β, IL-6 and IL-1ra concentrations in various brain areas of the rat. European cytokine network. 2008;19(1):8-14. link
77. Chennaoui M, Drogou C, Gomez-Merino D. Effects of physical training on IL-1β, IL-6 and IL-1ra concentrations in various brain areas of the rat. Eur Cytokine Netw 2008;19(1):8-14. PMID: 18299269
78. Gustafson B, Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006;281(14):9507-16. PMID: 16464856 [DOI:10.1074/jbc.M512077200]
79. Leite MR, Cechella JL, Mantovani AC, Duarte MM, Nogueira CW, Zeni G. Swimming exercise and diphenyl diselenide-supplemented diet affect the serum levels of pro-and anti-inflammatory cytokines differently depending on the age of rats. Cytokine 2015;71(1):119-23. PMID: 25307207 [DOI:10.1016/j.cyto.2014.09.006]
80. Jahangiri RJ, Farzanegi P, Habibian MH. The effect of aerobic training and arbotin on cardiac nitric oxide, tumor necrosis factor alpha, and vascular endothelial growth factor in male diabetic rats. Qom Univ Med Sci J 2017;11(5):53-62. Link
81. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22(9):791-7. PMID: 11350112
82. Heled Y, Dror Y, Moran DS, Rosenzweig T, Sampson SR, Epstein Y, et al. Physical exercise increases the expression of TNFα and GLUT 1 in muscle tissue of diabetes prone Psammomys obesus. Life Sci 2005; 77(23):2977-85. PMID: 16043194 [DOI:10.1016/j.lfs.2005.05.033]
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Soori R, Vahdat H, Shabkhiz F, Ababzadeh S, Eslami Farsani M. Effects of Aerobic Exercise and Rosemary Extracts on Inflammatory Factors in Cerebellar of Male Old Rats. Qom Univ Med Sci J. 2020; 14 (4) :11-21
URL: http://journal.muq.ac.ir/article-1-2518-fa.html

سوری رحمان، وحدت حسن، شب خیز فاطمه، آب آب زاده شیما، اسلامی فارسانی محسن. تأثیر تمرین هوازی و عصاره رزماری بر فاکتورهای التهابی در مخچه رت‌های نر مسن. مجله دانشگاه علوم پزشکی قم. 1399; 14 (4) :11-21

URL: http://journal.muq.ac.ir/article-1-2518-fa.html



دوره 14، شماره 4 - ( تیر 1399 ) برگشت به فهرست نسخه ها
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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