Volume 16, Issue 4 (July 2022)
Qom Univ Med Sci J 2022, 16(4): 330-341 |
Back to browse issues page
Ethics code: IR.QOM.REC.1399.023
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Delshad A, Salimi F, Heydariyeh N, Ababzadeh S. Effect of Endurance Exercise on Lipid Peroxidation Level and Total Antioxidant Capacity of Testicular Tissue in Adult Male Rats With Cadmium-induced Infertility. Qom Univ Med Sci J 2022; 16 (4) :330-341
URL: http://journal.muq.ac.ir/article-1-3426-en.html
URL: http://journal.muq.ac.ir/article-1-3426-en.html
1- Department of Sports Science, Faculty of Literature and Humanities, Qom University, Qom, Iran.
2- Department of Sports Science, Faculty of Physical Education, Toloo Mehr Institute of Higher Education Qom, Qom, Iran. ,Fereshte.salimi13@gmail.com
3- Department of Biology, Faculty of Basic Sciences, Qom Branch, Islamic Azad University, Qom, Iran.
4- Department of Anatomy, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Department of Sports Science, Faculty of Physical Education, Toloo Mehr Institute of Higher Education Qom, Qom, Iran. ,
3- Department of Biology, Faculty of Basic Sciences, Qom Branch, Islamic Azad University, Qom, Iran.
4- Department of Anatomy, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Abstract: (1362 Views)
Background and Objectives: Cadmium (Cd) can induce lipid peroxidation, increase malondialdehyde (MDA), and reduce total oxidative capacity (TAC) in the testis by producing free radicals and, as a result, cause infertility. This study aims to determine the effect of a period of endurance exercise on MDA levels and TAC of testicular tissue in adult male rats with infertility induced by cadmium chloride.
Methods: In this experimental study, 32 healthy adult male Wistar rats weighing 250±30 g and aged 12 weeks were used, which were randomly divided into four groups of control (n=8), exercise (n=8), Cd (n=8), and Cd+exercise (n=8). The endurance exercise program was presented at five sessions per week for 5 weeks. Data were analyzed in SPSS software, version 24 using one-way analysis of variance and by the Least Significant Difference post hoc test. The significance level was set at 0.05.
Results: The MDA and TAC in the exercise group were increased significantly compared to the control group (P<0.05), indicating that moderate-intensity endurance exercise significantly increased the TAC and MDA of testicular tissue in Cd-induced infertility. Cd increased oxidative stress markers and reduced antioxidant enzymes. Moderate-intensity endurance exercise significantly increased the antioxidant enzymes.
Conclusion: Given the effects of moderate-intensity endurance exercise in rats with Cd-induced infertility, it can be said that these exercises can make the body more resistant to oxidative stress products.
Methods: In this experimental study, 32 healthy adult male Wistar rats weighing 250±30 g and aged 12 weeks were used, which were randomly divided into four groups of control (n=8), exercise (n=8), Cd (n=8), and Cd+exercise (n=8). The endurance exercise program was presented at five sessions per week for 5 weeks. Data were analyzed in SPSS software, version 24 using one-way analysis of variance and by the Least Significant Difference post hoc test. The significance level was set at 0.05.
Results: The MDA and TAC in the exercise group were increased significantly compared to the control group (P<0.05), indicating that moderate-intensity endurance exercise significantly increased the TAC and MDA of testicular tissue in Cd-induced infertility. Cd increased oxidative stress markers and reduced antioxidant enzymes. Moderate-intensity endurance exercise significantly increased the antioxidant enzymes.
Conclusion: Given the effects of moderate-intensity endurance exercise in rats with Cd-induced infertility, it can be said that these exercises can make the body more resistant to oxidative stress products.
Type of Study: Original Article |
Subject:
فیزیولوژی ورزشی
Received: 2022/03/13 | Accepted: 2022/05/18 | Published: 2022/04/30
Received: 2022/03/13 | Accepted: 2022/05/18 | Published: 2022/04/30
References
1. Yan X, Dong L, Liu Y, Yang F, Tan K, Li J, et al. Effects of physical exercises on semen quality and reproductive outcomes in male infertility: A protocol for systematic review and Meta-Synthesis of randomized controlled trials. Medicine. 2019; 98(41):e17494. I:10.1097/MD.0000000000017494] [PMID] [PMCID] [DOI:10.1097/MD.0000000000017494]
2. ES HB, El-Yamany MA. Chemical and nutraceutical studies on infertility of albino rats induced by cadmium chloride. Pak J Bio Sci. 2020; 23(10):1245-52. [DOI:10.3923/pjbs.2020.1245.1252] [PMID] [DOI:10.3923/pjbs.2020.1245.1252]
3. Li X, Yao Z, Yang D, Jiang X, Sun J, Tian L, et al. Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage. J Hazard Mater. 2020; 387:121706. [DOI:10.1016/j.jhazmat.2019.121706] [PMID] [DOI:10.1016/j.jhazmat.2019.121706]
4. Olaniyi KS, Amusa OA, Oniyide AA, Ajadi IO, Akinnagbe NT, Babatunde SS. Protective role of glutamine against cadmium-induced testicular dysfunction in Wistar rats: Involvement of G6PD activity. Life Sci. 2020; 242:117250. [DOI:10.1016/j.lfs.2019.117250] [PMID] [DOI:10.1016/j.lfs.2019.117250]
5. Kheradmand A. [Improvement of sperm evaluation parameters following ghrelin treatment in cadmium-induced testicular injury in rats (Persian)]. J Isfahan Med Sch. 2014; 31(265):2053-62. [Link]
6. Skolarczyk J, Budzynski M, Pekar J, Malecka-Massalska T, Skorzynska-Dziduszko K. The impact of cadmium on male infertility. J Elem. 2018; 23(1). [DOI:10.5601/jelem.2017.22.2.132]
7. Barati E, Nikzad H, Karimian M. Oxidative stress and male infertility: Current knowledge of pathophysiology and role of antioxidant therapy in disease management. Cell Mol Life Sci. 2020; 77(1):93-113. [DOI:10.1007/s00018-019-03253-8] [PMID] [DOI:10.1007/s00018-019-03253-8]
8. Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, et al. The effect of antioxidants on male factor infertility: The males, antioxidants, and infertility (MOXI) randomized clinical trial. Fertil Steril. 2020; 113(3):552-60.e3. [DOI:10.1016/j.fertnstert.2019.11.008] [PMID] [PMCID] [DOI:10.1016/j.fertnstert.2019.11.008]
9. Ranchordas MK, Rogerson D, Soltani H, Costello JT. Antioxidants for preventing and reducing muscle soreness after exercise: A cochrane systematic review. Br J Sports Med. 2020; 54(2):74-8. [DOI:10.1136/bjsports-2018-099599] [PMID] [DOI:10.1136/bjsports-2018-099599]
10. Thirupathi A, Wang M, Lin JK, Fekete G, István B, Baker JS, et al. Effect of different exercise modalities on oxidative stress: A systematic review. Biomed Res Int. 2021; 2021:1947928. [DOI:10.1155/2021/1947928] [PMID] [PMCID] [DOI:10.1155/2021/1947928]
11. Higgins MR, Izadi A, Kaviani M. Antioxidants and exercise performance: With a focus on vitamin E and C supplementation. Int J Environ Res Public Health. 2020; 17(22):8452. [DOI:10.3390/ijerph17228452] [PMID] [PMCID] [DOI:10.3390/ijerph17228452]
12. Khoobkhahi N, Delavar R, Nayebifar S. The combinatory effects of combined training (endurance-resistance) and garlic supplementation on oxidative stress and antioxidant adaptations in untrained boys. Sci Sports. 2019; 34(6):410.e1-7. [DOI:10.1016/j.scispo.2019.05.007] [DOI:10.1016/j.scispo.2019.05.007]
13. Golbidi S, Badran M, Laher I. Antioxidant and anti-inflammatory effects of exercise in diabetic patients.Exp Diabetes Res. 2012; 2012:941868. [DOI:10.1155/2012/941868] [PMID] [PMCID] [DOI:10.1155/2012/941868]
14. Ahmadi M, Abbassi Daloii A, Shadmehri S, Aghaei Bahmanbeglu N. Compare the effect of eight weeks aerobic and resistance training on oxidant, antioxidant status and lipid profile in obese girls. J Sport Exerc Physiol. 2018; 11(1):139-52. [Link]
15. Satilmiş N, Çimen L, Çeti̇n İC, Polat Y, Çimen B. Effects of aerobic exercise on oxidant/antioxidant status in obese boys: A controlled trial. Exp Appl Med Sci. 2021; 2(1):117-27. [DOI:10.46871/eams.2021.15] [DOI:10.46871/eams.2021.15]
16. Qin F, Xu MX, Wang ZW, Han ZN, Dong YN, Zhao JX. Effect of aerobic exercise and different levels of fine particulate matter (PM2.5) on pulmonary response in Wistar rats. Life Sci. 2020; 254:117355 [DOI:10.1016/j.lfs.2020.117355] [PMID] [DOI:10.1016/j.lfs.2020.117355]
17. Usefpor M, Ghasemnian AA, Rahmani A. [The effect of a period of high intensive interval training on total antioxidant capacity and level of liver tissue malondialdehyde in male Wistar rats (Persian)]. Sci J Kurdistan Univ Med Sci. 2017; 22(5):103-10. [DOI:10.22102/22.5.103]
18. de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV, Simões. The antioxidant effect of exercise: A systematic review and Meta-Synthesis. Sports Med. 2017; 47(2):277-93. [DOI:10.1007/s40279-016-0566-1] [PMID] [DOI:10.1007/s40279-016-0566-1]
19. Ghahreman E, Eidi A, Mortazavi P, Oryan S. [Protective effect of purslane (portulaca oleracea) on cadmium chloride-induced testicular damage in adult male Wistar rats (Persian)]. J Comp Pathobiol Iran. 2019; 16(3):2883-92. [Link]
20. Afzalpour ME, Taheri Chadorneshin H, Foadoddini M, Abtahi Eivari H. Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav. 2015; 147:78-83. [DOI:10.1016/j.physbeh.2015.04.012] [PMID] [DOI:10.1016/j.physbeh.2015.04.012]
21. Nikokalam Nazif N, Khosravi M, Ahmadi R, Bananej M, Majd A. Effect of treadmill exercise on catalepsy and the expression of the BDNF gene in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced parkinson in male NMRI mice. Iran J Basic Med Sci. 2020; 23(4):483-93. [DOI:10.22038/ijbms.2020.37707.8960] [PMID] [PMCID]
22. Fraga CG, Oteiza PI, Galleano M. In vitro measurements and interpretation of total antioxidant capacity. Biochim Biophys Acta. 2014; 1840(2):931-4. [DOI:10.1016/j.bbagen.2013.06.030] [PMID] [DOI:10.1016/j.bbagen.2013.06.030]
23. Rezaei S, Abbassi Daloi A, Barari Ar, Ahmadi M. [Effect of eight weeks aerobic training on the levels of antioxidant enzymes in the heart tissue of type 2 diabetic rats (Persian)]. J Anim Physiol Dev. 2020; 13(4):49-60. [Link]
24. Tofas T, Fatouros IG, Draganidis D, Deli CK, Chatzinikolaou A, Tziortzis C, et al. Effects of cardiovascular, resistance and combined exercise training on cardiovascular, performance and blood redox parameters in coronary artery disease patients: An 8-month training-detraining randomized intervention. Antioxidants. 2021; 10(3):409. [DOI:10.3390/antiox10030409] [PMID] [PMCID] [DOI:10.3390/antiox10030409]
25. Emadi S, Azamian Jazi A, Hemati S. [Effect of 6 weeks of low-volume high-intensity interval training on antioxidant defense and aerobic power in female survivors of breast cancer (Persian)]. Med J Mashhad Univ Med Sci. 2018; 60(6):779-91. [DOI:10.22038/MJMS.2018.10742]
26. Bagheri Najafbad A, Sharifi G, Mirzaei A. [Comparsion of oxidative stress index and plasma antioxidant capacity among female handball atheletes and non athlete females (Persian)]. Armaghan-e-Danesh. 2012; 17(4):349-58. [Link]
27. Parastesh M, Yousefvand Z, Moghadasi S. [Comparison of the effect of moderate-intensity interval training (MICT) and high-intensity interval training (HIIT) on testicular structure, serum level of malondialdehyde and total antioxidant capacity of male diabetic rats (Persian)]. Daneshvar Med. 2020; 27(2):27-40. [DOI:10.22070/27.141.27]
28. Zhang G, Jiang F, Chen Q, Yang H, Zhou N, Sun L, et al. Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity. Environ Int. 2020; 136:105483. [DOI:10.1016/j.envint.2020.105483] [PMID] [DOI:10.1016/j.envint.2020.105483]
29. Algul S, Ugras S, Kara M. Comparative evaluation of MDA levels during aerobic exercise in young trained and sedentary male subjects. East J Med. 2018; 23(2):98-101. [DOI:10.5505/ejm.2018.40469] [DOI:10.5505/ejm.2018.40469]
30. Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Anal Biochem. 2017; 524:13-30. [DOI:10.1016/j.ab.2016.10.021] [PMID] [DOI:10.1016/j.ab.2016.10.021]
31. Chehreii S, Momeni H, Atabaki Z. [Effect of curcumin on plasma membrane integrity and stress oxidative factors testis and serum in mice treated with cadmium chloride (Persian)]. Cell Tissue J. 2018; 9(1):1-11. [DOI:10.52547/JCT.9.1.1]
32. Li X, Sun G, Zhu W, Wang Y. Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis. Genet Mol Res. 2015; 14(4):12367-76. [DOI:10.4238/2015.October.16.3] [PMID] [DOI:10.4238/2015.October.16.3]
33. Afrundeh R, Khajehlandi M, Mohammadi R. [Comparison of the effect of 6 weeks aerobic training on the activity of catalase enzyme and malondialdehyde in heart tissue of healthy and streptozotocin-diabetic male wistar rats (intervention: Experimental) (Persian)]. Stud Med Sci. 2019; 30(5):337-46. [Link]
34. Kanter M, Aksu F, Takir M, Kostek O, Kanter B, Oymagil A. Effects of low intensity exercise against apoptosis and oxidative stress in streptozotocin-induced diabetic rat heart.Exp Clin Endocrinol Diabetes. 2017; 125(09):583-91. [DOI:10.1055/s-0035-1569332] [PMID] [DOI:10.1055/s-0035-1569332]
35. Abdollahi S, Mohamadzadeh Salamat K, Azizbeigi K, Etemad Z. [The effect of 4 weeks of aerobic training and octapamine on the levels of malondialdehyde and caspase 3 in brown adipose tissue in rats received deeply heated oils treatment (Persian)]. J Jiroft Univ Med Sci. 2020; 7(2):394-403. [Link]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Owned by Qom University of Medical Sciences
Published by Qom University of Medical Sciences Press
eISSN: 2008-1375
pISSN: 1735-7799
Email: journal[at]muq.ac.ir
j.mua.ac[at]gmail.com
