[Home ] [Archive]   [ فارسی ]  
:: ::
:: Volume 16, Issue 9 (December 2022) ::
2022, 16(9): 0-0 Back to browse issues page
The effectiveness of atorvastatin in reducing inflammatory indicators and the duration of hospitalization of patients with corona virus in Shahid Beheshti Hospital, Qom, 1400
Reihane Tabaraii , Akram Asghari , Leila Jafari * 1, Mostafa Vahedian , Mohammad Bagherzadeh , Jamshid Vafaee manesh
1- , jafari.leila1@yahoo.com
Abstract:   (180 Views)
Background and  Objectives
Acute coronavirus syndrome (SARS-CoV) plays an important role in stimulating inflammatory pathways in causing various covid19 manifestations. Considering the anti-inflammatory role of statins and modulating the inflammatory process dependent on cytokines, the hypothesis of a possible effect of this group of drugs in inhibiting inflammatory cascade  of cytokines in the field of coronavirus have been proposed in some studies, so the aim of this trial was to evaluate the anti-inflammatory effect of atorvastatin in addition to standard protocol therapy compared to standard protocol treatment separately for hospitalized adults with COVID-19.

Method: We conducted a randomized controlled clinical trial on adults hospitalized with COVID-19. Patients were divided   randomly into a treatment group receiving atorvastatin+ standard protocol   and a control group receiving standard  protocol alone. The findings were analyzed by SPSS 22 software )  Chi square, paired t.test and ANOVA( and P.value less than 0.05 was considered statistically significant.
Results:74 patients with a 1: 1 ratio in the atorvastatin and control groups were studied and included in the study. Clinical and demographic characteristics were similar between the two groups. CRP level in atorvastatin group decreased significantly (P <0.05) so that on the Thirtieth day there was a significant difference in CRP level between the two groups (P = 0.01). There was no significant difference in O2sat on discharge day. Although the duration of hospitalization in the atorvastatin group was significantly reduced compared to the control group (P <0.05), but there was no significant difference in receiving aggressive mechanical ventilation or hospitalization in the ICU.

Conclusion: Our results showed that the use of atorvastatin with standard  protocol of covid19 treatment in hospitalized patients  can significantly reduce the number of hospitalization days in these patients. Also, the mean CRP in the atorvastatin  group decreased significantly after 30 days


 
Keywords: Coronavirus disease . Atorvastatin .CRP
     
Type of Study: Original Article | Subject: داخلی
Received: 2022/09/26 | Accepted: 2022/11/6 | Published: 2022/11/1
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: (IR.MUQ.REC.1399.176)
Clinical trials code: IRCT20201128049508N1


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tabaraii R, asghari A, jafari L, vahedian M, bagherzadeh M, vafaee manesh J. The effectiveness of atorvastatin in reducing inflammatory indicators and the duration of hospitalization of patients with corona virus in Shahid Beheshti Hospital, Qom, 1400. Qom University of Medical Sciences Journal 2022; 16 (9)
URL: http://journal.muq.ac.ir/article-1-3575-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 9 (December 2022) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 30 queries by YEKTAWEB 4538