Volume 16, Issue 11 (February 2023)                   Qom Univ Med Sci J 2023, 16(11): 0-0 | Back to browse issues page

Ethics code: IR.MUQ.AEC.1400.002

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Komeili-Movahhed T, Moslehi A. Protective effect of rosmarinic acid on changes of hepatic cells inflammation in non-alcoholic steatohepatitis model in male mice: focus on role of cy-clooxygenase 2/ Prostaglandin E2 pathway. Qom Univ Med Sci J 2023; 16 (11)
URL: http://journal.muq.ac.ir/article-1-3582-en.html
1- Cellular & Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
Abstract:   (410 Views)
Background and objective: Non alcoholic steatohepatitis (NASH) is one of the common liver diseases, identifying by excess lipid accumulation (steatosis) and inflammation in the liver. inflammation is one of principal reasons for cause and promotion of this disease which takes place from different pathways. Rosmarinic acid (RA) is considered as an antioxidant and anti-inflammatory product, which has positive effects on improvement of liver injuries. The aim of this study was to evaluate protective effect of rosmarinic acid on decrement of liver inflammation induced by non alcoholic steatohepatitis in male mice through effect on cyclooxygenase 2/ Prostaglandin E2 and matrix metalloprotenase9 (MMP9) pathway
Methods: In this study, 24 C57/BL6 male mice were used. The animals were divided into 4 equal groups, including; Control, Rosmarinic acid (RA), NASH and NASH- RA groups. In 3th and 4th groups, non alcoholic steatohepatitis was induced by methionine-choline deficient (MCD) diet during 8 weeks. In the RA and NASH-RA groups, the animals were received rosmarinic acid daily intraperitoneally. After 8 weeks, the animals were sacrificed and obtained liver samples. Hematoxilin and eosin staining was preformed to histological evaluation and real time PCR and ELISA assays were used for molecular studies.
Results: this study showed that rosmarinic acid improved hepatic steatosis and inflammation. Rosmarinic acid also decreased MMP9 and cyclooxygenase 2 expressions and finally hepatic levels of prostaglandin E2 declines significantly.
Conclusion: It seems that rosmarinic acid could reduce liver inflammation and thereby improve male mice induced non alcoholic steatohepatitis via decrement of genes expression of  cyclooxygenase 2 enzyme and MMP9 and decrease of prostaglandin E2 concentration.
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2022/10/2 | Accepted: 2022/12/19 | Published: 2023/01/1

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