1- Islamic Azad university
2- Islamic Azad university ,h.zarei@iautmu.ac.ir
2- Islamic Azad university ,
Abstract: (413 Views)
Background and Objectives: Sleep deprivation can increase the level of anxiety by impairing hippocampal-dependent memory and emotional memory and cause changes in mood and mental disorder, cognitive and motor functions. NR1-NR2 dimer is the main structure of functional organization in any NDMA receptor. Fish oil contains omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have important biochemical functions.
Methods: Number of 25 male Wistar rats were randomly divided into 5 groups: control, Sham, sleep deprivation (SD), Sham with fish oil and sleep deprivation with fish oil. At the end of the treatment period, the brain of rats was removed and the amount of NR1 and NR2 proteins in the hippocampus was assessed by Western blotting.
Results: No difference in the level of NR1 and NR2 proteins was observed in the hippocampus of sham compared to the control group. The expression of these two proteins in the group treated with fish oil increased by 62.8% and 83.3%, respectively, while in the SD group there was no significant difference compared to the control group. On the other hand, the levels of these two proteins in the SD group treated with fish oil compared to the SD group increased by 50 and 116.7%, respectively.
Conclusion: The use of fish oil can play a protective and therapeutic role in controlling and improving the effects of SD, which reduces the expression of these proteins in other areas of the brain.
Methods: Number of 25 male Wistar rats were randomly divided into 5 groups: control, Sham, sleep deprivation (SD), Sham with fish oil and sleep deprivation with fish oil. At the end of the treatment period, the brain of rats was removed and the amount of NR1 and NR2 proteins in the hippocampus was assessed by Western blotting.
Results: No difference in the level of NR1 and NR2 proteins was observed in the hippocampus of sham compared to the control group. The expression of these two proteins in the group treated with fish oil increased by 62.8% and 83.3%, respectively, while in the SD group there was no significant difference compared to the control group. On the other hand, the levels of these two proteins in the SD group treated with fish oil compared to the SD group increased by 50 and 116.7%, respectively.
Conclusion: The use of fish oil can play a protective and therapeutic role in controlling and improving the effects of SD, which reduces the expression of these proteins in other areas of the brain.
Article number: 2762.1
Type of Study: Original Article |
Subject:
ژنتیک
Received: 2022/11/10 | Accepted: 2023/08/16 | Published: 2024/04/29
Received: 2022/11/10 | Accepted: 2023/08/16 | Published: 2024/04/29
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