Volume 18 -                   Qom Univ Med Sci J 2024, 18 - : 0-0 | Back to browse issues page

‎ 10.32598/qums.18.65.9
Ethics code: IR.MUQ.AEC.1401.030

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Effect of chlorogenic acid on the heart tissue in male C57/Bl6 mice induced endoplasmic reticulum stress
Fatemeh Heidari1 , Tahereh Komeili-Movahhed2 , Azam Moslehi * 3
1- Qom University of Medical Sciences,, Qom, Iran
2- , Qom University of Medical Sciences, Qom, Iran
3- Qom University of Medical Sciences, Qom, Iran , moslehi2000@gmail.com
Abstract:   (352 Views)
Background and objective: Endoplasmic reticulum (ER) stress is considered as one of important factors in fatty liver, infertility, gastric ulcer and even cardiac disorders pathophysiology. Chlorogenic acid is a known herbal agent with many antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the protective effects  of chlorogenic acid on decrement of endoplasmic reticulum stress induced by tunicamycin in the heart of male C57/Bl6 mice.  Methods: In this study animals were categorized into six groups: Saline, Vehicle, chlorogenic acid, ER stress, ER stress-chlorogenic acid 20mg and ER stress-chlorogenic acid 50mg. ER stress was induced by tunicamycin in mice intraperitoneally. One hour before injection, 20 mg and 50 mg chlorogenic acid were administrated intraperitoneally. After 30 hours of tunicamycin injection, the animals were sacrificed and a part of the heart was kept in 10% formaldehyde and another part kept in -80oc. Histological and cellular evaluations were then preformed. Results: Findings of this study showed that chlorogenic acid alleviated GRP78 mRNA and malondehaldeaid levels, while total antioxidant capacity increased after chlorogenic acid administration. Decreased fibers cross section and increased interventricular thickness induced by ER stress also improved. Conclusion: These findings show that chlorogenic acid can improve histological and cellular changes induced by endoplasmic reticulum stress in the heart through of oxidative stress and endoplasmic reticulum stress attenuation in male C57/Bl6 mice.
Article number: 65.9
Keywords: Chlorogenic acid, Endoplasmic reticulum stress, Heart, Tunicamycin, Oxidative stress
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Type of Study: Original Article | Subject: فیزیولوژی
Received: 2023/11/15 | Accepted: 2023/12/16 | Published: 2024/04/29
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