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Qom Univ Med Sci J 2016, 10(2): 88-99 Back to browse issues page
Mesenchymal Stem Cells and the Prospect of its Application in the Treatment of stroke
Kobra Akhoundzadeh *1, Abedin Vakili2, Manoochehr Safari3
1- Qom University of Medical Sciences, Qom, Iran. , mehr2057@gmail.com
2- Department of Physiology, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran
3- Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Abstract:   (5799 Views)

Despite extensive medical advances, stroke is still one of the major problems in health care system. Researchers are seeking novel therapeutic strategies for the treatment of stroke, such as cell-therapy. In this regard, mesenchymal stem cells are the most used cells in stroke cell-therapy researches. Mesenchymal stem cells are multipotent cells capable of self-renewal and differentiation, which can be derived from various tissues, such as bone marrow, skeletal muscle, adipose tissue, umbilical cord, and synovium. In this review article, after description of mesenchymal stem cells, the studies related to use of these cells in stroke as well as the challenges ahead in the field of stroke cell therapy, were mentioned.

According to existing studies, although it seems that use of mesenchymal stem cells transplantation has a bright prospect in the treatment of stroke, there are still some issues, such as apoptosis of grafted cell, neural differentiation of stem cell, likelihood of malignancy of transplanted cell, unwanted cell differentiation, and migration to ischemic region, have overshadowed its clinical application.

Keywords: Mesenchymal stem cell, Stroke, Brain ischemia, Stem cell transplantation.
Full-Text [PDF 653 kb]   (2452 Downloads)    
Type of Study: Review Article |
Received: 2016/04/17 | Accepted: 2016/04/17 | Published: 2016/04/17
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Akhoundzadeh K, Vakili A, Safari M. Mesenchymal Stem Cells and the Prospect of its Application in the Treatment of stroke. Qom Univ Med Sci J 2016; 10 (2) :88-99
URL: http://journal.muq.ac.ir/article-1-725-en.html


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Volume 10, Issue 2 (April 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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