Volume 11, Issue 7 (September 2017)
Qom Univ Med Sci J 2017, 11(7): 12-20 |
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barari A, farzanegi P, bashiri J, kochpideh F, gholami F. Effect of 6 Weeks of Swimming Training and Aloe vera Extract Supplementation on the Serum levels of Cyclooxygenase-2 and Vascular Endothelial Growth Factor in Mice with Breast Cancer. Qom Univ Med Sci J 2017; 11 (7) :12-20
URL: http://journal.muq.ac.ir/article-1-911-en.html
URL: http://journal.muq.ac.ir/article-1-911-en.html
1- Department of Physical Education & Sport Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , lireza54.barari@gmail.com
2- Department of Physical Education & Sport Sciences, Sari Branch, Islamic Azad University, Sari, Iran.
3- Department of Physical Education & Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
4- Department of Physical Education & Sport Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
5- Faculty of Physical Education & Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
2- Department of Physical Education & Sport Sciences, Sari Branch, Islamic Azad University, Sari, Iran.
3- Department of Physical Education & Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
4- Department of Physical Education & Sport Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
5- Faculty of Physical Education & Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
Abstract: (6109 Views)
Background and Objectives: Regular physical activity is associated with improved quality of life and reductions of cancer-related mortality, but the underlying mechanisms are unclear. Moreover, Aloe vera may have anti-tumor and anti-inflammatory effects. In the current study, the effect of 6 weeks of swimming trainings along with Aloe vera supplementation, was investigated on serum levels of cyclooxygenase-2 and vascular endothelial growth factor in mice with breast cancer.
Methods: In this quasi-experimental study, 35Balb/c mice were acclimatized with laboratory conditions and swimming trainings, then mouse adenocarcinoma tumor balk was transplanted subcutaneously and after a week, they were divided into 7-animal groups, including exercise, exercise + extract, extract, and control (cancer). The fifth group )as the healthy control( included 7 mice. The exercise groups underwent swimming training for 6 weeks, and the extract groups also received 300mg/kg/day of aloe vera extract for 6 weeks. Blood samples were taken from the right ventricle 48 hours after the last session. The data were analyzed using one-way ANOVA at the significance level of p<0.05.
Results: The serum levels of COX-2 and VEGF significantly increased with tumor induction (p<0.05). After 6 weeks, VEGF levels in both exercise groups and COX-2 levels in the extract group, were lower compared to the cancer control group (p<0.05); However, these levels were higher than the healthy control group.
Conclusion: Based on the results, swimming and aloe vera supplementation may attenuate the increase of circulatory levels of COX-2 and VEGF caused by tumor induction but cannot normalize the elevated levels.
Methods: In this quasi-experimental study, 35Balb/c mice were acclimatized with laboratory conditions and swimming trainings, then mouse adenocarcinoma tumor balk was transplanted subcutaneously and after a week, they were divided into 7-animal groups, including exercise, exercise + extract, extract, and control (cancer). The fifth group )as the healthy control( included 7 mice. The exercise groups underwent swimming training for 6 weeks, and the extract groups also received 300mg/kg/day of aloe vera extract for 6 weeks. Blood samples were taken from the right ventricle 48 hours after the last session. The data were analyzed using one-way ANOVA at the significance level of p<0.05.
Results: The serum levels of COX-2 and VEGF significantly increased with tumor induction (p<0.05). After 6 weeks, VEGF levels in both exercise groups and COX-2 levels in the extract group, were lower compared to the cancer control group (p<0.05); However, these levels were higher than the healthy control group.
Conclusion: Based on the results, swimming and aloe vera supplementation may attenuate the increase of circulatory levels of COX-2 and VEGF caused by tumor induction but cannot normalize the elevated levels.
Type of Study: Original Article |
Subject:
فیزیولوژی ورزشی
Received: 2016/06/10 | Accepted: 2016/08/10 | Published: 2017/09/20
Received: 2016/06/10 | Accepted: 2016/08/10 | Published: 2017/09/20
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