Volume 12, Issue 2 (April 2018)
Qom Univ Med Sci J 2018, 12(2): 28-34 |
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Abolfathirad S, Sari S, Mirfakhraie R. An Association Study of rs2829803 Polymorphism in miRNA-155 with Multiple Sclerosis in Patients Referred to Farshchian Hospital of Hamadan City, (Iran). Qom Univ Med Sci J 2018; 12 (2) :28-34
URL: http://journal.muq.ac.ir/article-1-1392-en.html
URL: http://journal.muq.ac.ir/article-1-1392-en.html
1- Department of Cellular & Molecular Sciences, Faculty of Advanced Science & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- 1Department of Cellular & Molecular Sciences, Faculty of Advanced Science & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- 1Department of Cellular & Molecular Sciences, Faculty of Advanced Science & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Abstract: (5590 Views)
Background and Objectives: Multiple sclerosis is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and polymorphisms have been known to be associated with it. In this study, the correlation between polymorphism of rs2829803 in miR-155 and multiple sclerosis, was investigated in the patients referred to Farshchian Hospital of Hamadan City.
Methods: In this case-control study, 130 patients (29% male, 71% female) with multiple sclerosis (age range, 17-69 years) and 150 healthy subjects (38% male, 62% female) (age range, 19-63 years), were selected as the control group. Genotyping was performed by Tetra-ARMS-PCR method.
Results: A significant difference was observed in the genotypic distribution of miR-155 rs2829803 in dominant form (OR: 0.33, 95% CI: 1.19-0.58) (p=0.0001) and heterozygote (OR: 1.92, 95% CI:1.17-3.16) (p=0.01) in patients compared to the healthy subjects.
Conclusion: In line with previous studies on the relationship between miR-155 polymorphism (rs2829803) and multiple sclerosis disease, the results of this study confirmed the association of this polymorphism with increased risk of developing the disease.
Methods: In this case-control study, 130 patients (29% male, 71% female) with multiple sclerosis (age range, 17-69 years) and 150 healthy subjects (38% male, 62% female) (age range, 19-63 years), were selected as the control group. Genotyping was performed by Tetra-ARMS-PCR method.
Results: A significant difference was observed in the genotypic distribution of miR-155 rs2829803 in dominant form (OR: 0.33, 95% CI: 1.19-0.58) (p=0.0001) and heterozygote (OR: 1.92, 95% CI:1.17-3.16) (p=0.01) in patients compared to the healthy subjects.
Conclusion: In line with previous studies on the relationship between miR-155 polymorphism (rs2829803) and multiple sclerosis disease, the results of this study confirmed the association of this polymorphism with increased risk of developing the disease.
Type of Study: Original Article |
Subject:
سلولی و مولکولی
Received: 2016/12/26 | Accepted: 2017/02/7 | Published: 2018/04/15
Received: 2016/12/26 | Accepted: 2017/02/7 | Published: 2018/04/15
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Published by Qom University of Medical Sciences Press
eISSN: 2008-1375
pISSN: 1735-7799
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