[Home ] [Archive]   [ فارسی ]  
:: ::
:: Volume 13, Issue 7 (September 2019) ::
Qom Univ Med Sci J 2019, 13(7): 22-28 Back to browse issues page
The Cytotoxic Effect of Hyssop Extract on Breast Cancer Cell Line
Faranak Fallahian1 , Nafiseh Mahdavi2, Mohammadreza Haeri 3
1- Department of Clinical Biochemistry, School of Medicine, Qom University of Medical Sciences
2- Depatment of Biology, School of Basic Sciences, Payame noor University, Tehran
3- Department of Clinical Biochemistry, School of Medicine, Qom University of Medical Sciences , haeri.mr@gmail.com
Abstract:   (2627 Views)
Background and Objectives: Given the rising prevalence of breast cancer in Iran over the past two decades and also high mortality rate of the patients, and on the other hand, according to oral administration, low cost, and easy public access to hyssop (Hyssopus officinalis), in this study, the effectiveness of this herbal product, was investigated on MCF-7 breast cancer cell line.
 
Methods: In this experimental study, MCF-7 cells were cultured in RPMI 1640 medium containing 10% fetal bovine serum (FBS) and 5% CO2 at 37°C with concentrations of 10-1000µg/mL of the hyssop extract. To evaluate the cytotoxic effect of the extract on the cells, colorimetric method MTT, was used and the viability rate of the cells was determined. The results were analyzed by t-test.
 
Results: In this study, using colorimetric method MTT, after 72 hours, the methanol extract of hyssop flower in the concentration of more than 500µg/mL, could reduce the chances of viability of MCF-7 cells from 100% to 60%, while the ethanol extract of hyssop leaves has little effect on death of MCF-7 cancer cells.
 
Conclusion: According to the results of this study, it seems that methanol extract of hyssop flower has a significant cytotoxic effect on MCF-7 cell. Therefore, with further research on active substancesof this plant, it can be used in the treatment of cancer in the future.
Keywords: Breast neoplasms, phytotherapy, Hyssopus officinalis
Full-Text [PDF 901 kb]   (429 Downloads)    
Type of Study: Original Article | Subject: طب سنتی
Received: 2017/01/9 | Accepted: 2019/07/30 | Published: 2019/09/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fallahian F, Mahdavi N, Haeri M. The Cytotoxic Effect of Hyssop Extract on Breast Cancer Cell Line. Qom Univ Med Sci J. 2019; 13 (7) :22-28
URL: http://journal.muq.ac.ir/article-1-1413-en.html


Volume 13, Issue 7 (September 2019) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 30 queries by YEKTAWEB 4294